BS_49852ZBH
pilocytic astrocytoma
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- pilocytic astrocytoma
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- pilocytic astrocytoma
- overall_survival_months
- 21.846254927726676
- age_years
- 4.403
- sex
- Male
GSVA pathway preview (0 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | BS_BKQZ550R | pilocytic astrocytoma | — | 0.936 |
| 2 | BS_VARR255N | pilocytic astrocytoma | — | 0.933 |
| 3 | BS_ZZMYDZJW | pilocytic astrocytoma | — | 0.930 |
| 4 | BS_MBSTWZA6 | pilocytic astrocytoma | — | 0.929 |
| 5 | BS_HV8PFRBR | pilocytic astrocytoma | — | 0.917 |
| 6 | BS_SDZY6RZ3 | pilocytic astrocytoma | — | 0.917 |
| 7 | BS_NS7GSHB9 | pilocytic astrocytoma | — | 0.915 |
| 8 | BS_FJWZ3M7V | low-grade glioma | — | 0.913 |
| 9 | BS_T0RKFEKR | pilocytic astrocytoma | — | 0.913 |
| 10 | BS_SHMC4902 | pilocytic astrocytoma | — | 0.910 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 39 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PROTEIN_SECRETION | 0.549 | Remibrutinib | — uncovered |
| CHOLESTEROL_HOMEOSTASIS | 0.509 | Remibrutinib | — uncovered |
| TGF_BETA_SIGNALING | 0.485 | Inavolisib | — uncovered |
| INTERFERON_ALPHA_RESPONSE | 0.482 | Inavolisib | — uncovered |
| TNFA_SIGNALING_VIA_NFKB | 0.467 | Inavolisib | — uncovered |
| ANDROGEN_RESPONSE | 0.439 | Inavolisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.436 | Remibrutinib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.415 | Idelalisib | — uncovered |
| ADIPOGENESIS | 0.410 | Inavolisib | — uncovered |
| IL6_JAK_STAT3_SIGNALING | 0.391 | Inavolisib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.379 | Inavolisib | — uncovered |
| MTORC1_SIGNALING | 0.326 | Inavolisib | — uncovered |
| APOPTOSIS | 0.309 | Idelalisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.299 | Inavolisib | — uncovered |
| COMPLEMENT | 0.292 | Inavolisib | — uncovered |
| INFLAMMATORY_RESPONSE | 0.292 | Idelalisib | — uncovered |
| P53_PATHWAY | 0.291 | Idelalisib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.269 | Inavolisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.267 | Idelalisib | — uncovered |
| COAGULATION | 0.264 | Binimetinib | — uncovered |