198b23eb-5efa-4c7e-84f6-96976474de0b
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
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- cancer_type_detailed
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- subtype
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GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- EPITHELIAL_MESENCHYMAL_TRANSITION+0.500
- INTERFERON_ALPHA_RESPONSE+0.500
- ANGIOGENESIS+0.400
- INTERFERON_GAMMA_RESPONSE+0.400
- HEDGEHOG_SIGNALING+0.300
- IL6_JAK_STAT3_SIGNALING+0.300
- INFLAMMATORY_RESPONSE+0.300
- KRAS_SIGNALING_UP+0.300
- MITOTIC_SPINDLE+0.300
- NOTCH_SIGNALING+0.300
Top 10 suppressed
- BILE_ACID_METABOLISM-0.300
- CHOLESTEROL_HOMEOSTASIS-0.300
- ESTROGEN_RESPONSE_EARLY-0.300
- ESTROGEN_RESPONSE_LATE-0.300
- FATTY_ACID_METABOLISM-0.300
- HEME_METABOLISM-0.300
- OXIDATIVE_PHOSPHORYLATION-0.300
- ADIPOGENESIS-0.200
- KRAS_SIGNALING_DN-0.200
- MYC_TARGETS_V2-0.200
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR8613802 | — | D | 0.887 |
| 2 | TCGA-CR-7382-01A-11R-2132-07 | — | — | 0.871 |
| 3 | SRR8518214 | — | D | 0.846 |
| 4 | 6a43f966-cb2b-47ee-b0f4-c269707daa88 | — | — | 0.821 |
| 5 | TCGA-44-7662-01A-11R-2066-07 | — | cohortA1 | 0.814 |
| 6 | TCGA-D8-A1XT-01A-11R-A14M-07 | — | C | 0.800 |
| 7 | SAMN03290942 | — | — | 0.800 |
| 8 | TCGA-A2-A0SX-01A-12R-A084-07 | — | D | 0.799 |
| 9 | SRR650184 | — | — | 0.798 |
| 10 | TCGA-FD-A3SP-01A-31R-A22U-07 | — | — | 0.796 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 26 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| EPITHELIAL_MESENCHYMAL_TRANSITION | 0.500 | Inavolisib | — uncovered |
| INTERFERON_ALPHA_RESPONSE | 0.500 | Inavolisib | — uncovered |
| ANGIOGENESIS | 0.400 | Remibrutinib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.400 | Idelalisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.300 | Inavolisib | — uncovered |
| IL6_JAK_STAT3_SIGNALING | 0.300 | Inavolisib | — uncovered |
| INFLAMMATORY_RESPONSE | 0.300 | Idelalisib | — uncovered |
| KRAS_SIGNALING_UP | 0.300 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.300 | Inavolisib | — uncovered |
| NOTCH_SIGNALING | 0.300 | Inavolisib | — uncovered |
| TGF_BETA_SIGNALING | 0.300 | Inavolisib | — uncovered |
| ALLOGRAFT_REJECTION | 0.200 | Idelalisib | — uncovered |
| COMPLEMENT | 0.200 | Inavolisib | — uncovered |
| E2F_TARGETS | 0.200 | Inavolisib | — uncovered |
| G2M_CHECKPOINT | 0.200 | Inavolisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.200 | Idelalisib | — uncovered |
| UV_RESPONSE_DN | 0.200 | Inavolisib | — uncovered |
| APICAL_JUNCTION | 0.100 | Inavolisib | — uncovered |
| APOPTOSIS | 0.100 | Idelalisib | — uncovered |
| COAGULATION | 0.100 | Binimetinib | — uncovered |