Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · head-neck@1

SRR2932846

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ba2431bc-2edc-5a8a-b33d-e8708d37d45d

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
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cancer_type_detailed
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subtype
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sex
male

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • OXIDATIVE_PHOSPHORYLATION+0.480
  • E2F_TARGETS+0.470
  • MYC_TARGETS_V1+0.430
  • G2M_CHECKPOINT+0.310
  • CHOLESTEROL_HOMEOSTASIS+0.280
  • FATTY_ACID_METABOLISM+0.270
  • SPERMATOGENESIS+0.270
  • DNA_REPAIR+0.260
  • PROTEIN_SECRETION+0.220
  • ADIPOGENESIS+0.200

Top 10 suppressed

  • HEDGEHOG_SIGNALING-0.530
  • EPITHELIAL_MESENCHYMAL_TRANSITION-0.390
  • WNT_BETA_CATENIN_SIGNALING-0.370
  • INTERFERON_GAMMA_RESPONSE-0.330
  • UV_RESPONSE_DN-0.330
  • INTERFERON_ALPHA_RESPONSE-0.320
  • ANGIOGENESIS-0.290
  • APICAL_JUNCTION-0.290
  • MYOGENESIS-0.290
  • IL6_JAK_STAT3_SIGNALING-0.280

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR8518448
breast-umap@18
—C0.928
2TCGA-P3-A5QF-01A-11R-A28V-07
head-neck@1
——0.901
3BSR_14_0066_A2_S94
breast-umap@18
—C0.883
4SRR2932839
head-neck@1
——0.883
5TCGA-22-5491-01A-01R-1635-07
lung-landscapes@6
—cohortSQ20.881
6fd49c74b-2a85-46cd-aaa0-dbd2f1284947
colon-landscapes@1
——0.881
7SRR10900014
melanoma-umap@29
——0.877
8TCGA-B6-A0X5-01A-21R-A109-07
breast-umap@18
—B0.875
9TCGA-BA-A4IG-01A-11R-A266-07
head-neck@1
——0.874
10dfb9c45f-cb52-4e36-b663-1a9e8c7c0b47
colon-landscapes@1
——0.869

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 25 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
OXIDATIVE_PHOSPHORYLATION0.480Remibrutinib— uncovered
E2F_TARGETS0.470Inavolisib— uncovered
MYC_TARGETS_V10.430Inavolisib— uncovered
G2M_CHECKPOINT0.310Inavolisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.280Remibrutinib— uncovered
FATTY_ACID_METABOLISM0.270Inavolisib— uncovered
SPERMATOGENESIS0.270Inavolisib— uncovered
DNA_REPAIR0.260Idelalisib— uncovered
PROTEIN_SECRETION0.220Remibrutinib— uncovered
ADIPOGENESIS0.200Inavolisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.190Inavolisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.180Inavolisib— uncovered
MTORC1_SIGNALING0.170Inavolisib— uncovered
HEME_METABOLISM0.160Temsirolimus— uncovered
P53_PATHWAY0.150Idelalisib— uncovered
PEROXISOME0.150Idelalisib— uncovered
PANCREAS_BETA_CELLS0.140Cobimetinib— uncovered
XENOBIOTIC_METABOLISM0.100Inavolisib— uncovered
MYC_TARGETS_V20.080Idelalisib— uncovered
ESTROGEN_RESPONSE_LATE0.070Idelalisib— uncovered