Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · head-neck@1

SRR6079991

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bb6dff06-5dda-5842-ad78-7ed58b664271

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
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cancer_type_detailed
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subtype
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sex
female

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

8 twins match this tumor's tissue · 2 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1MBCProject_0170_T1_RNA
breast-umap@18
—C0.624
2TCGA-OR-A5JE-01
acc-tcga-pancan-2018@2018
Adrenocortical CarcinomaAdrenocortical Carcinoma, Usual Type0.610
3EFE4B0DB-A0DC-482E-88F8-B530E76A4BB0
brain-umap@2
——0.608
4TCGA-39-5024-01A-21R-1820-07
lung-landscapes@6
—cohortSQ10.604
5TCGA-C8-A26W-01A-11R-A16F-07
breast-umap@18
—C0.601
6SRR6079995
head-neck@1
——0.588
7SRR15069616
head-neck@1
——0.571
8SRR12475167
colon-landscapes@1
——0.569
9TCGA-A8-A07Z-01A-11R-A00Z-07
breast-umap@18
—B0.567
10BS_6MZ7FRZH
brain-umap@2
Supratentorial Ependymoma—0.567

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 29 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
E2F_TARGETS0.510Inavolisib— uncovered
INTERFERON_ALPHA_RESPONSE0.430Inavolisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.400Remibrutinib— uncovered
FATTY_ACID_METABOLISM0.370Inavolisib— uncovered
G2M_CHECKPOINT0.370Inavolisib— uncovered
MYC_TARGETS_V10.370Inavolisib— uncovered
PANCREAS_BETA_CELLS0.370Cobimetinib— uncovered
ADIPOGENESIS0.330Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.300Idelalisib— uncovered
PEROXISOME0.270Idelalisib— uncovered
INTERFERON_GAMMA_RESPONSE0.260Idelalisib— uncovered
UV_RESPONSE_UP0.250Idelalisib— uncovered
NOTCH_SIGNALING0.230Inavolisib— uncovered
BILE_ACID_METABOLISM0.170Inavolisib— uncovered
DNA_REPAIR0.170Idelalisib— uncovered
ESTROGEN_RESPONSE_EARLY0.170Inavolisib— uncovered
ANDROGEN_RESPONSE0.150Inavolisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.150Inavolisib— uncovered
XENOBIOTIC_METABOLISM0.150Inavolisib— uncovered
KRAS_SIGNALING_DN0.100Remibrutinib— uncovered