Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

SRR934791

bc14fdec-eb15-5899-9197-8e27c30762af

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
128.15374507227332
age_years
36
sex
Male

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • PROTEIN_SECRETION+0.402
  • MYC_TARGETS_V1+0.389
  • MITOTIC_SPINDLE+0.346
  • ANDROGEN_RESPONSE+0.336
  • CHOLESTEROL_HOMEOSTASIS+0.331
  • TGF_BETA_SIGNALING+0.325
  • E2F_TARGETS+0.304
  • G2M_CHECKPOINT+0.303
  • NOTCH_SIGNALING+0.249
  • DNA_REPAIR+0.248

Top 10 suppressed

  • KRAS_SIGNALING_DN-0.416
  • MYOGENESIS-0.364
  • ANGIOGENESIS-0.320
  • APICAL_SURFACE-0.302
  • COAGULATION-0.301
  • REACTIVE_OXYGEN_SPECIES_PATHWAY-0.300
  • ESTROGEN_RESPONSE_LATE-0.274
  • EPITHELIAL_MESENCHYMAL_TRANSITION-0.246
  • HYPOXIA-0.229
  • ALLOGRAFT_REJECTION-0.212

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR934777
brain-umap@2
0.932
2EFEDAFE3-FF81-47ED-97F6-1193EA375D77
brain-umap@2
0.904
3SRR934799
brain-umap@2
0.901
4A5D67B9F-5558-48FC-81A3-642D1903DA1F
brain-umap@2
0.897
57A392761-6834-4B60-A49A-99D0D2AEC612
brain-umap@2
0.895
66EE50ED0-9F0E-4393-B165-257D5C03F221
brain-umap@2
0.895
7D5E8379B-621C-4551-9B13-E63B1B068488
brain-umap@2
0.894
84992152D-1D3D-4156-9D80-1B6810AAE78F
brain-umap@2
0.885
9E79FE058-F03E-45F3-A939-356B0427E1B7
brain-umap@2
0.878
1068CE8E02-F24A-4580-9881-DFBB288E2ED7
brain-umap@2
0.876

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 27 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
PROTEIN_SECRETION0.402Remibrutinib— uncovered
MYC_TARGETS_V10.389Inavolisib— uncovered
MITOTIC_SPINDLE0.346Inavolisib— uncovered
ANDROGEN_RESPONSE0.336Inavolisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.331Remibrutinib— uncovered
TGF_BETA_SIGNALING0.325Inavolisib— uncovered
E2F_TARGETS0.304Inavolisib— uncovered
G2M_CHECKPOINT0.303Inavolisib— uncovered
NOTCH_SIGNALING0.249Inavolisib— uncovered
DNA_REPAIR0.248Idelalisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.244Idelalisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.235Inavolisib— uncovered
MTORC1_SIGNALING0.165Inavolisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.136Remibrutinib— uncovered
HEDGEHOG_SIGNALING0.126Inavolisib— uncovered
MYC_TARGETS_V20.124Idelalisib— uncovered
UV_RESPONSE_DN0.114Inavolisib— uncovered
P53_PATHWAY0.085Idelalisib— uncovered
FATTY_ACID_METABOLISM0.068Inavolisib— uncovered
ADIPOGENESIS0.057Inavolisib— uncovered