Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · bladder-landscape@3

SRR26320070

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bf27a967-f25b-5f5d-80ad-523ba1733888

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
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cancer_type_detailed
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subtype
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sex
Female

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-AC-A3HN-01A-11R-A213-07
breast-umap@18
—A0.950
2R163
bladder-landscape@3
——0.948
3SRR12475153
colon-landscapes@1
——0.931
4TCGA-CN-6016-01A-11R-1686-07
head-neck@1
——0.924
5TCGA-CV-6934-01A-11R-1915-07
head-neck@1
——0.923
6TCGA-78-8648-01A-11R-2403-07
lung-landscapes@6
—cohortMD20.921
7TCGA-50-8459-01A-11R-2326-07
lung-landscapes@6
—cohortMD20.919
8TCGA-BH-A0AZ-01A-21R-A12P-07
breast-umap@18
—A0.913
9SRR8518425
breast-umap@18
—A0.912
102cec663c-00c8-48b5-967b-f2a53c0fb409
colon-landscapes@1
——0.909

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 28 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
EPITHELIAL_MESENCHYMAL_TRANSITION0.550Inavolisib— uncovered
HEDGEHOG_SIGNALING0.500Inavolisib— uncovered
UV_RESPONSE_DN0.450Inavolisib— uncovered
MYOGENESIS0.440Inavolisib— uncovered
APICAL_JUNCTION0.390Inavolisib— uncovered
COAGULATION0.360Binimetinib— uncovered
IL6_JAK_STAT3_SIGNALING0.350Inavolisib— uncovered
ALLOGRAFT_REJECTION0.320Idelalisib— uncovered
COMPLEMENT0.320Inavolisib— uncovered
TGF_BETA_SIGNALING0.320Inavolisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.320Inavolisib— uncovered
APICAL_SURFACE0.300Temsirolimus— uncovered
KRAS_SIGNALING_UP0.300Inavolisib— uncovered
ANGIOGENESIS0.270Remibrutinib— uncovered
NOTCH_SIGNALING0.270Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.230Idelalisib— uncovered
IL2_STAT5_SIGNALING0.220Idelalisib— uncovered
PANCREAS_BETA_CELLS0.200Cobimetinib— uncovered
HYPOXIA0.180Idelalisib— uncovered
INTERFERON_GAMMA_RESPONSE0.170Idelalisib— uncovered