C3N-00167
— · cohortA1
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- cohortA1
- subtype
- cohortA1
- age_years
- 64.45722108
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- COAGULATION+0.320
- BILE_ACID_METABOLISM+0.300
- KRAS_SIGNALING_DN+0.280
- MYOGENESIS+0.240
- XENOBIOTIC_METABOLISM+0.220
- PANCREAS_BETA_CELLS+0.200
- HEDGEHOG_SIGNALING+0.150
- APICAL_JUNCTION+0.120
- SPERMATOGENESIS+0.080
- NOTCH_SIGNALING+0.060
Top 10 suppressed
- G2M_CHECKPOINT-0.580
- MYC_TARGETS_V1-0.570
- E2F_TARGETS-0.560
- MYC_TARGETS_V2-0.530
- UNFOLDED_PROTEIN_RESPONSE-0.480
- MTORC1_SIGNALING-0.410
- OXIDATIVE_PHOSPHORYLATION-0.380
- PI3K_AKT_MTOR_SIGNALING-0.380
- DNA_REPAIR-0.350
- MITOTIC_SPINDLE-0.320
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
7 twins match this tumor's tissue · 3 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | C3N-03210 | — | cohortA1 | 0.910 |
| 2 | TCGA-97-A4M1-01A-11R-A24X-07 | — | cohortA1 | 0.905 |
| 3 | SRR1466641 | GTEX | — | 0.878 |
| 4 | TCGA-62-8397-01A-11R-2326-07 | — | cohortA1 | 0.877 |
| 5 | SRR1417505 | GTEX | — | 0.877 |
| 6 | TCGA-L9-A50W-01A-12R-A39D-07 | — | cohortA1 | 0.873 |
| 7 | MNG4 | — | — | 0.873 |
| 8 | SRR1379450 | GTEX | — | 0.871 |
| 9 | TCGA-97-8552-01A-11R-2403-07 | — | cohortA1 | 0.871 |
| 10 | TCGA-55-8616-01A-11R-2403-07 | — | cohortA1 | 0.870 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 12 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| COAGULATION | 0.320 | Binimetinib | — uncovered |
| BILE_ACID_METABOLISM | 0.300 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.280 | Remibrutinib | — uncovered |
| MYOGENESIS | 0.240 | Inavolisib | — uncovered |
| XENOBIOTIC_METABOLISM | 0.220 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.200 | Cobimetinib | — uncovered |
| HEDGEHOG_SIGNALING | 0.150 | Inavolisib | — uncovered |
| APICAL_JUNCTION | 0.120 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.080 | Inavolisib | — uncovered |
| NOTCH_SIGNALING | 0.060 | Inavolisib | — uncovered |
| TGF_BETA_SIGNALING | 0.040 | Inavolisib | — uncovered |
| PEROXISOME | 0.020 | Idelalisib | — uncovered |