MNG786
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PANCREAS_BETA_CELLS+0.346
- KRAS_SIGNALING_DN+0.316
- SPERMATOGENESIS+0.169
- APICAL_SURFACE+0.098
- ESTROGEN_RESPONSE_EARLY+0.074
- ESTROGEN_RESPONSE_LATE+0.035
- COAGULATION-0.009
- KRAS_SIGNALING_UP-0.035
- TGF_BETA_SIGNALING-0.039
- HEDGEHOG_SIGNALING-0.041
Top 10 suppressed
- MYC_TARGETS_V2-0.615
- OXIDATIVE_PHOSPHORYLATION-0.615
- MYC_TARGETS_V1-0.607
- MTORC1_SIGNALING-0.548
- DNA_REPAIR-0.542
- UNFOLDED_PROTEIN_RESPONSE-0.542
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.531
- INTERFERON_ALPHA_RESPONSE-0.503
- CHOLESTEROL_HOMEOSTASIS-0.464
- PROTEIN_SECRETION-0.464
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
7 twins match this tumor's tissue · 3 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | MNG1131 | — | — | 0.944 |
| 2 | MNG226 | — | — | 0.944 |
| 3 | SRR12696743 | — | — | 0.943 |
| 4 | SRR1516040 | — | — | 0.943 |
| 5 | MNG225 | — | — | 0.943 |
| 6 | SRR650204 | — | — | 0.942 |
| 7 | BS_CQSAJ7BF | DNET | — | 0.942 |
| 8 | MNG1231 | — | — | 0.940 |
| 9 | SRR1362417 | GTEX | — | 0.939 |
| 10 | BS_23W9EPFE | Ganglioglioma | — | 0.938 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 6 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PANCREAS_BETA_CELLS | 0.346 | Cobimetinib | — uncovered |
| KRAS_SIGNALING_DN | 0.316 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.169 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.098 | Temsirolimus | — uncovered |
| ESTROGEN_RESPONSE_EARLY | 0.074 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_LATE | 0.035 | Idelalisib | — uncovered |