Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · brain-umap@2

SRR597977

GTEX

c3623a82-5f23-5e8e-8018-4c2db15fa4e4

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
GTEX
cancer_type_detailed
—
subtype
—
cancer_type
GTEX
sex
Male

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • IL6_JAK_STAT3_SIGNALING+0.571
  • ALLOGRAFT_REJECTION+0.546
  • ANGIOGENESIS+0.537
  • INFLAMMATORY_RESPONSE+0.525
  • INTERFERON_GAMMA_RESPONSE+0.455
  • INTERFERON_ALPHA_RESPONSE+0.450
  • COAGULATION+0.438
  • TNFA_SIGNALING_VIA_NFKB+0.415
  • EPITHELIAL_MESENCHYMAL_TRANSITION+0.412
  • COMPLEMENT+0.402

Top 10 suppressed

  • OXIDATIVE_PHOSPHORYLATION-0.547
  • DNA_REPAIR-0.448
  • MYC_TARGETS_V1-0.367
  • PROTEIN_SECRETION-0.334
  • MYC_TARGETS_V2-0.327
  • MITOTIC_SPINDLE-0.277
  • ADIPOGENESIS-0.265
  • E2F_TARGETS-0.247
  • UV_RESPONSE_DN-0.211
  • HEDGEHOG_SIGNALING-0.206

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

8 twins match this tumor's tissue · 2 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR1498482
brain-umap@2
GTEX—0.944
2SRR1469495
brain-umap@2
GTEX—0.940
3SRR1329885
brain-umap@2
GTEX—0.939
4SRR1382532
brain-umap@2
GTEX—0.936
5SRR615934
brain-umap@2
GTEX—0.931
6SRR1084484
brain-umap@2
GTEX—0.929
7SRR818469
brain-umap@2
GTEX—0.927
8SRR1316254
brain-umap@2
GTEX—0.924
9BS_3H71BH6Q
brain-umap@2
Ganglioglioma—0.916
10BS_PJPGVD62
medullo-epn-umap@date-based
EPNEPN Tumor0.914

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 30 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
IL6_JAK_STAT3_SIGNALING0.571Inavolisib— uncovered
ALLOGRAFT_REJECTION0.546Idelalisib— uncovered
ANGIOGENESIS0.537Remibrutinib— uncovered
INFLAMMATORY_RESPONSE0.525Idelalisib— uncovered
INTERFERON_GAMMA_RESPONSE0.455Idelalisib— uncovered
INTERFERON_ALPHA_RESPONSE0.450Inavolisib— uncovered
COAGULATION0.438Binimetinib— uncovered
TNFA_SIGNALING_VIA_NFKB0.415Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.412Inavolisib— uncovered
COMPLEMENT0.402Inavolisib— uncovered
IL2_STAT5_SIGNALING0.382Idelalisib— uncovered
KRAS_SIGNALING_UP0.365Inavolisib— uncovered
MYOGENESIS0.357Inavolisib— uncovered
KRAS_SIGNALING_DN0.315Remibrutinib— uncovered
ESTROGEN_RESPONSE_LATE0.282Idelalisib— uncovered
PANCREAS_BETA_CELLS0.282Cobimetinib— uncovered
APOPTOSIS0.262Idelalisib— uncovered
HYPOXIA0.235Idelalisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.219Inavolisib— uncovered
ESTROGEN_RESPONSE_EARLY0.216Inavolisib— uncovered