SRR1313145
— · D
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- D
- subtype
- D
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- G2M_CHECKPOINT+0.410
- E2F_TARGETS+0.370
- MITOTIC_SPINDLE+0.290
- WNT_BETA_CATENIN_SIGNALING+0.180
- SPERMATOGENESIS+0.120
- EPITHELIAL_MESENCHYMAL_TRANSITION+0.100
- DNA_REPAIR+0.020
- KRAS_SIGNALING_DN+0.020
- MYOGENESIS+0.020
- NOTCH_SIGNALING+0.020
Top 10 suppressed
- ESTROGEN_RESPONSE_EARLY-0.500
- INTERFERON_ALPHA_RESPONSE-0.460
- FATTY_ACID_METABOLISM-0.390
- ESTROGEN_RESPONSE_LATE-0.380
- PANCREAS_BETA_CELLS-0.380
- ADIPOGENESIS-0.360
- MYC_TARGETS_V2-0.360
- BILE_ACID_METABOLISM-0.330
- PI3K_AKT_MTOR_SIGNALING-0.320
- XENOBIOTIC_METABOLISM-0.310
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
7 twins match this tumor's tissue · 3 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | TCGA-58-8388-01A-11R-2326-07 | — | cohortSQ1 | 0.834 |
| 2 | a9e8922f-fd6c-412d-85f5-40f5ea9b5455 | — | — | 0.819 |
| 3 | MNG790 | — | — | 0.817 |
| 4 | BS_9FHSNVS0 | ATRT | — | 0.815 |
| 5 | TCGA-AC-A2QH-01B-04R-A22O-07 | — | D | 0.803 |
| 6 | SRR10899974 | — | — | 0.796 |
| 7 | BS_S1M423AB | Embryonal tumors | — | 0.790 |
| 8 | 20120197.TNBC | — | D | 0.790 |
| 9 | BS_4E1G7E3G | ATRT | — | 0.786 |
| 10 | TCGA-BA-4078-01A-01R-1436-07 | — | — | 0.784 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 11 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| G2M_CHECKPOINT | 0.410 | Inavolisib | — uncovered |
| E2F_TARGETS | 0.370 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.290 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.180 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.120 | Inavolisib | — uncovered |
| EPITHELIAL_MESENCHYMAL_TRANSITION | 0.100 | Inavolisib | — uncovered |
| DNA_REPAIR | 0.020 | Idelalisib | — uncovered |
| KRAS_SIGNALING_DN | 0.020 | Remibrutinib | — uncovered |
| MYOGENESIS | 0.020 | Inavolisib | — uncovered |
| NOTCH_SIGNALING | 0.020 | Inavolisib | — uncovered |
| TNFA_SIGNALING_VIA_NFKB | 0.020 | Inavolisib | — uncovered |