Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · mng-umap@100

MNG209

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c6d596f2-0b7a-524f-a04c-e628a6b70a2c

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
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cancer_type_detailed
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subtype
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GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • G2M_CHECKPOINT+0.338
  • E2F_TARGETS+0.316
  • ESTROGEN_RESPONSE_LATE+0.281
  • ESTROGEN_RESPONSE_EARLY+0.257
  • MYOGENESIS+0.241
  • ANGIOGENESIS+0.232
  • MTORC1_SIGNALING+0.216
  • REACTIVE_OXYGEN_SPECIES_PATHWAY+0.191
  • MITOTIC_SPINDLE+0.153
  • ADIPOGENESIS+0.147

Top 10 suppressed

  • MYC_TARGETS_V1-0.347
  • PROTEIN_SECRETION-0.328
  • TNFA_SIGNALING_VIA_NFKB-0.300
  • WNT_BETA_CATENIN_SIGNALING-0.289
  • ALLOGRAFT_REJECTION-0.259
  • TGF_BETA_SIGNALING-0.250
  • MYC_TARGETS_V2-0.205
  • UNFOLDED_PROTEIN_RESPONSE-0.198
  • DNA_REPAIR-0.195
  • UV_RESPONSE_DN-0.130

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1MNG566
mng-umap@100
——0.563
2MNG91
mng-umap@100
——0.558
3MNG825
mng-umap@100
——0.553
4MNG1244
mng-umap@100
——0.552
5s0099994
melanoma-umap@29
——0.551
6MNG854
mng-umap@100
——0.542
7SRR8943039
bladder-landscape@3
——0.540
8MNG157
mng-umap@100
——0.537
9MNG254
mng-umap@100
——0.535
10MNG370
mng-umap@100
——0.535

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 23 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
G2M_CHECKPOINT0.338Inavolisib— uncovered
E2F_TARGETS0.316Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.281Idelalisib— uncovered
ESTROGEN_RESPONSE_EARLY0.257Inavolisib— uncovered
MYOGENESIS0.241Inavolisib— uncovered
ANGIOGENESIS0.232Remibrutinib— uncovered
MTORC1_SIGNALING0.216Inavolisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.191Inavolisib— uncovered
MITOTIC_SPINDLE0.153Inavolisib— uncovered
ADIPOGENESIS0.147Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.145Inavolisib— uncovered
PEROXISOME0.129Idelalisib— uncovered
HEDGEHOG_SIGNALING0.127Inavolisib— uncovered
KRAS_SIGNALING_DN0.126Remibrutinib— uncovered
GLYCOLYSIS0.123Inavolisib— uncovered
APICAL_JUNCTION0.116Inavolisib— uncovered
HYPOXIA0.090Idelalisib— uncovered
XENOBIOTIC_METABOLISM0.060Inavolisib— uncovered
ANDROGEN_RESPONSE0.058Inavolisib— uncovered
P53_PATHWAY0.054Idelalisib— uncovered