Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.
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20ed86b0-2e3d-44ec-88cd-eac5486fe15c

c6f84689-6123-5483-99be-d74afbb0d656

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
age_years
90

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • EPITHELIAL_MESENCHYMAL_TRANSITION+0.350
  • MYC_TARGETS_V2+0.340
  • HEDGEHOG_SIGNALING+0.320
  • MYC_TARGETS_V1+0.270
  • APICAL_JUNCTION+0.210
  • WNT_BETA_CATENIN_SIGNALING+0.200
  • PANCREAS_BETA_CELLS+0.190
  • MYOGENESIS+0.180
  • ANGIOGENESIS+0.170
  • NOTCH_SIGNALING+0.170

Top 10 suppressed

  • INTERFERON_ALPHA_RESPONSE-0.650
  • INTERFERON_GAMMA_RESPONSE-0.590
  • ALLOGRAFT_REJECTION-0.520
  • INFLAMMATORY_RESPONSE-0.430
  • IL6_JAK_STAT3_SIGNALING-0.390
  • COMPLEMENT-0.350
  • FATTY_ACID_METABOLISM-0.350
  • REACTIVE_OXYGEN_SPECIES_PATHWAY-0.300
  • BILE_ACID_METABOLISM-0.280
  • CHOLESTEROL_HOMEOSTASIS-0.280

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-NC-A5HP-01A-11R-A26W-07
lung-landscapes@6
cohortSQ10.847
2TCGA-AC-A5XU-01A-11R-A28M-07
breast-umap@18
B0.846
3b6c4399b-a4b6-4fcd-815c-554dc1a79ff7
melanoma-umap@29
0.822
4SRR2016936
head-neck@1
0.805
5701e70ac-31d2-4e78-95e1-3fa2bb466e83
colon-landscapes@1
0.804
6TCGA-P3-A6SX-01A-11R-A34R-07
head-neck@1
0.802
720130253.TNBC
breast-umap@18
E0.799
8ERR2208919
melanoma-umap@29
0.799
94e24bc58-d246-4c96-952a-a18f95d142b2
melanoma-umap@29
0.785
109a38d0dc-6b2c-439d-b10e-efd0f1cba209
melanoma-umap@29
0.781