8a25dfb0-edd0-4a44-9a6b-8f3f761b940c
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
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- subtype
- —
- age_years
- 65
GSVA pathway preview (0 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | fe036511-fe82-467c-9c6e-59bfb8b0a329 | — | — | 0.880 |
| 2 | TCGA-CV-7103-01A-21R-2016-07 | — | — | 0.862 |
| 3 | SRR33532761 | — | A | 0.858 |
| 4 | SRR8613752 | — | A | 0.855 |
| 5 | TCGA-A7-A5ZX-01A-12R-A29R-07 | — | A | 0.854 |
| 6 | d2995480-5ae0-42e1-9a21-25e1435201ee | — | — | 0.853 |
| 7 | BSR_10_0261_B3_S85 | — | A | 0.853 |
| 8 | d69e622a-6dee-48f3-bf06-7f6148d7472a | — | — | 0.852 |
| 9 | e3d71c3f-4e56-45fa-be88-2cf444b70a5c | — | — | 0.850 |
| 10 | ca7ac1e1-4c44-40a5-8094-eeebc0c2c5a2 | — | — | 0.850 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 11 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| HEDGEHOG_SIGNALING | 0.490 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.320 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.300 | Inavolisib | — uncovered |
| EPITHELIAL_MESENCHYMAL_TRANSITION | 0.240 | Inavolisib | — uncovered |
| TGF_BETA_SIGNALING | 0.150 | Inavolisib | — uncovered |
| MYOGENESIS | 0.140 | Inavolisib | — uncovered |
| PEROXISOME | 0.140 | Idelalisib | — uncovered |
| KRAS_SIGNALING_DN | 0.090 | Remibrutinib | — uncovered |
| BILE_ACID_METABOLISM | 0.040 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.020 | Inavolisib | — uncovered |
| ANGIOGENESIS | 0.010 | Remibrutinib | — uncovered |