BS_2SFTWNVE
medulloblastoma
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- medulloblastoma
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- medulloblastoma
- age_years
- 9.274
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- G2M_CHECKPOINT+0.201
- SPERMATOGENESIS+0.195
- E2F_TARGETS+0.164
- MITOTIC_SPINDLE+0.162
- PANCREAS_BETA_CELLS+0.154
- DNA_REPAIR+0.126
- PROTEIN_SECRETION+0.063
- HEME_METABOLISM-0.005
- MYC_TARGETS_V1-0.011
- HEDGEHOG_SIGNALING-0.064
Top 10 suppressed
- ANGIOGENESIS-0.675
- INTERFERON_ALPHA_RESPONSE-0.653
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.609
- INTERFERON_GAMMA_RESPONSE-0.609
- IL6_JAK_STAT3_SIGNALING-0.580
- TNFA_SIGNALING_VIA_NFKB-0.572
- INFLAMMATORY_RESPONSE-0.542
- CHOLESTEROL_HOMEOSTASIS-0.530
- ALLOGRAFT_REJECTION-0.513
- APOPTOSIS-0.506
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | BS_61E80SD6 | medulloblastoma | — | 0.980 |
| 2 | BS_5PJCHF6V | medulloblastoma | — | 0.974 |
| 3 | BS_ERWT0ZWE | medulloblastoma | — | 0.971 |
| 4 | BS_A14Z8BBK | medulloblastoma | — | 0.971 |
| 5 | BS_HTEPAKCM | medulloblastoma | — | 0.966 |
| 6 | BS_KN92S7YQ | medulloblastoma | — | 0.963 |
| 7 | BS_QRDT19KS | medulloblastoma | — | 0.958 |
| 8 | BS_QPPPGYP4 | medulloblastoma | — | 0.952 |
| 9 | BS_VMEX27TN | medulloblastoma | — | 0.949 |
| 10 | BS_J8G4SH4Z | medulloblastoma | — | 0.949 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 7 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| G2M_CHECKPOINT | 0.201 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.195 | Inavolisib | — uncovered |
| E2F_TARGETS | 0.164 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.162 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.154 | Cobimetinib | — uncovered |
| DNA_REPAIR | 0.126 | Idelalisib | — uncovered |
| PROTEIN_SECRETION | 0.063 | Remibrutinib | — uncovered |