Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

AUR-AD9I-TTM3-A-1-1-R-A542-39

· C

c986c87f-125d-5102-b758-42461bbff967

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
C
subtype
C

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • XENOBIOTIC_METABOLISM+0.560
  • OXIDATIVE_PHOSPHORYLATION+0.540
  • FATTY_ACID_METABOLISM+0.520
  • BILE_ACID_METABOLISM+0.490
  • COAGULATION+0.480
  • PEROXISOME+0.460
  • MYC_TARGETS_V2+0.430
  • ADIPOGENESIS+0.420
  • REACTIVE_OXYGEN_SPECIES_PATHWAY+0.420
  • PROTEIN_SECRETION+0.350

Top 10 suppressed

  • WNT_BETA_CATENIN_SIGNALING-0.350
  • INTERFERON_GAMMA_RESPONSE-0.340
  • INTERFERON_ALPHA_RESPONSE-0.330
  • ALLOGRAFT_REJECTION-0.320
  • HEDGEHOG_SIGNALING-0.320
  • INFLAMMATORY_RESPONSE-0.250
  • NOTCH_SIGNALING-0.250
  • EPITHELIAL_MESENCHYMAL_TRANSITION-0.240
  • G2M_CHECKPOINT-0.240
  • KRAS_SIGNALING_UP-0.220

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1AUR-AD9F-TTM3-A-1-1-R-A542-39
breast-umap@18
C0.852
2TCGA-E2-A14O-01A-31R-A115-07
breast-umap@18
B0.852
3TCGA-A8-A07P-01A-11R-A00Z-07
breast-umap@18
B0.824
4SRR6013510
lung-landscapes@6
cohortA40.796
5TCGA-E2-A1LB-01A-11R-A144-07
breast-umap@18
F0.794
6bf93be3e-d4f1-4efb-9841-ca8ad81b237e
colon-landscapes@1
0.788
7SRR1516101
bladder-landscape@3
0.787
8AUR-AD9F-TTM1-A-1-1-R-A542-39
breast-umap@18
C0.785
9SRR13311171
bladder-landscape@3
0.779
10C3N-01024
lung-landscapes@6
cohortA10.776

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 29 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
XENOBIOTIC_METABOLISM0.560Inavolisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.540Remibrutinib— uncovered
FATTY_ACID_METABOLISM0.520Inavolisib— uncovered
BILE_ACID_METABOLISM0.490Inavolisib— uncovered
COAGULATION0.480Binimetinib— uncovered
PEROXISOME0.460Idelalisib— uncovered
MYC_TARGETS_V20.430Idelalisib— uncovered
ADIPOGENESIS0.420Inavolisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.420Inavolisib— uncovered
PROTEIN_SECRETION0.350Remibrutinib— uncovered
MYC_TARGETS_V10.340Inavolisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.330Idelalisib— uncovered
DNA_REPAIR0.320Idelalisib— uncovered
ESTROGEN_RESPONSE_EARLY0.320Inavolisib— uncovered
GLYCOLYSIS0.270Inavolisib— uncovered
MTORC1_SIGNALING0.270Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.230Idelalisib— uncovered
UV_RESPONSE_UP0.210Idelalisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.200Remibrutinib— uncovered
HEME_METABOLISM0.190Temsirolimus— uncovered