Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · melanoma-umap@29

SRR2779097

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cc44e4ac-0ace-5470-bf95-a4108b91b2da

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
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cancer_type_detailed
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subtype
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GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • CHOLESTEROL_HOMEOSTASIS+0.300
  • PANCREAS_BETA_CELLS+0.300
  • WNT_BETA_CATENIN_SIGNALING+0.300
  • HYPOXIA+0.200
  • MTORC1_SIGNALING+0.200
  • OXIDATIVE_PHOSPHORYLATION+0.200
  • REACTIVE_OXYGEN_SPECIES_PATHWAY+0.200
  • SPERMATOGENESIS+0.200
  • UNFOLDED_PROTEIN_RESPONSE+0.200
  • XENOBIOTIC_METABOLISM+0.200

Top 10 suppressed

  • ALLOGRAFT_REJECTION-0.500
  • IL6_JAK_STAT3_SIGNALING-0.400
  • INTERFERON_GAMMA_RESPONSE-0.400
  • KRAS_SIGNALING_UP-0.400
  • ANGIOGENESIS-0.300
  • COMPLEMENT-0.300
  • EPITHELIAL_MESENCHYMAL_TRANSITION-0.300
  • INFLAMMATORY_RESPONSE-0.300
  • INTERFERON_ALPHA_RESPONSE-0.300
  • APICAL_SURFACE-0.200

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1f7ddd671-b2ba-4952-918b-07ae0ea84263
melanoma-umap@29
——0.839
2TCGA-UF-A71E-01A-31R-A34R-07
head-neck@1
——0.831
3ccfdc2a2-bb01-41c2-9ef1-98bbd1cfae22
melanoma-umap@29
——0.813
4TCGA-CV-6962-01A-11R-1915-07
head-neck@1
——0.803
5TCGA-BB-8601-01A-11R-2403-07
head-neck@1
——0.802
6cc1c7e4b-89a0-4d94-b9e5-293c2eacadd9
melanoma-umap@29
——0.802
7TCGA-33-AAS8-01A-11R-A405-07
lung-landscapes@6
—cohortSQ20.800
8TCGA-66-2766-01A-01R-0851-07
lung-landscapes@6
—cohortSQ20.794
9SRR8613749
breast-umap@18
—C0.786
1020110070.TNBC
breast-umap@18
—E0.783

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 21 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
CHOLESTEROL_HOMEOSTASIS0.300Remibrutinib— uncovered
PANCREAS_BETA_CELLS0.300Cobimetinib— uncovered
WNT_BETA_CATENIN_SIGNALING0.300Inavolisib— uncovered
HYPOXIA0.200Idelalisib— uncovered
MTORC1_SIGNALING0.200Inavolisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.200Remibrutinib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.200Inavolisib— uncovered
SPERMATOGENESIS0.200Inavolisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.200Idelalisib— uncovered
XENOBIOTIC_METABOLISM0.200Inavolisib— uncovered
DNA_REPAIR0.100Idelalisib— uncovered
E2F_TARGETS0.100Inavolisib— uncovered
FATTY_ACID_METABOLISM0.100Inavolisib— uncovered
GLYCOLYSIS0.100Inavolisib— uncovered
HEME_METABOLISM0.100Temsirolimus— uncovered
KRAS_SIGNALING_DN0.100Remibrutinib— uncovered
MYC_TARGETS_V10.100Inavolisib— uncovered
P53_PATHWAY0.100Idelalisib— uncovered
PEROXISOME0.100Idelalisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.100Inavolisib— uncovered