MDT-AP-0134
Med · Medulloblastoma
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- Med
- cancer_type_detailed
- —
- subtype
- Medulloblastoma
- cancer_type
- Med
- subtype
- Medulloblastoma
- overall_survival_months
- 12.96
- os_event
- true
- age_years
- 5
- sex
- M
- new_clusters
- C4
- umap1_2d
- 2.975768899
- umap2_2d
- 4.739656149
- umap1_3d
- 1.490115457
- umap2_3d
- -0.339682414
- umap3_3d
- -2.270939387
- dataset
- Med-Taylor
GSVA pathway preview (0 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
7 twins match this tumor's tissue · 3 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | MDT-AP-1377 | Med | Medulloblastoma | 0.913 |
| 2 | SRR975602 | — | — | 0.907 |
| 3 | BS_9NZ2D6AD | Med | Medulloblastoma | 0.907 |
| 4 | BS_YBJBSRHV | Embryonal tumors | — | 0.905 |
| 5 | MBCProject_4634_T1_RNA | — | E | 0.904 |
| 6 | BS_M84H3KXA | medulloblastoma | — | 0.903 |
| 7 | SAMN03290927 | — | — | 0.903 |
| 8 | MDT-AP-0202 | Med | Medulloblastoma | 0.902 |
| 9 | TCGA-CQ-A4CI-01A-11R-A266-07 | — | — | 0.900 |
| 10 | BS_YETBN0RQ | medulloblastoma | — | 0.900 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 15 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| MYC_TARGETS_V1 | 0.590 | Inavolisib | — uncovered |
| MYC_TARGETS_V2 | 0.590 | Idelalisib | — uncovered |
| E2F_TARGETS | 0.560 | Inavolisib | — uncovered |
| G2M_CHECKPOINT | 0.500 | Inavolisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.400 | Idelalisib | — uncovered |
| MTORC1_SIGNALING | 0.360 | Inavolisib | — uncovered |
| DNA_REPAIR | 0.300 | Idelalisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.220 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.220 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.130 | Inavolisib | — uncovered |
| GLYCOLYSIS | 0.100 | Inavolisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.080 | Remibrutinib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.070 | Inavolisib | — uncovered |
| PEROXISOME | 0.030 | Idelalisib | — uncovered |
| ANDROGEN_RESPONSE | 0.010 | Inavolisib | — uncovered |