Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-60-2715-01A-01R-0851-07

· cohortSQ1

ce80e940-f591-5875-8eb7-31976e3ef312

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
cohortSQ1
subtype
cohortSQ1
age_years
51

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

9 twins match this tumor's tissue · 1 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-99-AA5R-01A-11R-A39D-07
lung-landscapes@6
cohortA10.962
2TCGA-98-A53C-01A-11R-A262-07
lung-landscapes@6
cohortMD20.959
3SRR2771286
melanoma-umap@29
0.959
4MNG809
mng-umap@100
0.956
5DRR168569
bladder-landscape@3
0.956
6SRR12202441
bladder-landscape@3
0.953
7BS_2SHWPB5P
brain-umap@2
ganglioneuroblastoma0.949
8TCGA-A2-A0CO-01A-13R-A22K-07
breast-umap@18
A0.949
9sclcA055A_S52.txt
lung-landscapes@6
cohortMD20.945
10TCGA-98-A53H-01A-12R-A262-07
lung-landscapes@6
cohortA10.943

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 28 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
EPITHELIAL_MESENCHYMAL_TRANSITION0.490Inavolisib— uncovered
ANGIOGENESIS0.440Remibrutinib— uncovered
INTERFERON_ALPHA_RESPONSE0.440Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.410Idelalisib— uncovered
MYOGENESIS0.410Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.400Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.400Idelalisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.400Inavolisib— uncovered
ALLOGRAFT_REJECTION0.360Idelalisib— uncovered
COAGULATION0.340Binimetinib— uncovered
KRAS_SIGNALING_DN0.330Remibrutinib— uncovered
IL2_STAT5_SIGNALING0.320Idelalisib— uncovered
KRAS_SIGNALING_UP0.320Inavolisib— uncovered
APICAL_SURFACE0.290Temsirolimus— uncovered
COMPLEMENT0.260Inavolisib— uncovered
UV_RESPONSE_DN0.260Inavolisib— uncovered
HEDGEHOG_SIGNALING0.220Inavolisib— uncovered
APICAL_JUNCTION0.210Inavolisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.160Inavolisib— uncovered
P53_PATHWAY0.110Idelalisib— uncovered