Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

BS_T1DVKKJB

Supratentorial Ependymoma

d03fe6ac-e7ba-5ef5-ab69-18716ebe3c49

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
Supratentorial Ependymoma
cancer_type_detailed
subtype
cancer_type
Supratentorial Ependymoma
overall_survival_months
140.76872536136662
age_years
8.611

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • TNFA_SIGNALING_VIA_NFKB+0.467
  • HYPOXIA+0.389
  • ANGIOGENESIS+0.332
  • INFLAMMATORY_RESPONSE+0.323
  • WNT_BETA_CATENIN_SIGNALING+0.295
  • UV_RESPONSE_UP+0.289
  • PANCREAS_BETA_CELLS+0.257
  • INTERFERON_GAMMA_RESPONSE+0.254
  • INTERFERON_ALPHA_RESPONSE+0.244
  • GLYCOLYSIS+0.213

Top 10 suppressed

  • OXIDATIVE_PHOSPHORYLATION-0.318
  • PROTEIN_SECRETION-0.316
  • MYC_TARGETS_V1-0.288
  • MITOTIC_SPINDLE-0.213
  • MYC_TARGETS_V2-0.177
  • ANDROGEN_RESPONSE-0.148
  • TGF_BETA_SIGNALING-0.106
  • PEROXISOME-0.095
  • FATTY_ACID_METABOLISM-0.094
  • HEME_METABOLISM-0.093

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

3 twins match this tumor's tissue · 7 come from a different tissue of origin ← cross-tissue dominant

#SampleCancer typeSubtypecos similarity
1BS_T1DVKKJB
medullo-epn-umap@date-based
EPNSupratentorial EPN0.933
2SJEPD034_D.RNA-Seq
medullo-epn-umap@date-based
EPNSupratentorial EPN0.808
3BS_PJPGVD62
brain-umap@2
Ependymoma NOS0.802
4X41226e40.d143.43b1.ac92.023809990077
lung-landscapes@6
cohortA10.791
5SRR2778056
melanoma-umap@29
0.788
6BS_0QYS36NR
brain-umap@2
Ependymoma NOS0.783
7R107
bladder-landscape@3
0.780
8BS_RXN5T5YT
brain-umap@2
Diffuse intrinsic pontine glioma0.779
9BS_N4B1SZZH
medullo-epn-umap@date-based
MedMedulloblastoma0.772
10BS_6H1C1ME9
brain-umap@2
Posterior Fossa Ependymoma0.771

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 39 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
TNFA_SIGNALING_VIA_NFKB0.467Inavolisib— uncovered
HYPOXIA0.389Idelalisib— uncovered
ANGIOGENESIS0.332Remibrutinib— uncovered
INFLAMMATORY_RESPONSE0.323Idelalisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.295Inavolisib— uncovered
UV_RESPONSE_UP0.289Idelalisib— uncovered
PANCREAS_BETA_CELLS0.257Cobimetinib— uncovered
INTERFERON_GAMMA_RESPONSE0.254Idelalisib— uncovered
INTERFERON_ALPHA_RESPONSE0.244Inavolisib— uncovered
GLYCOLYSIS0.213Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.204Inavolisib— uncovered
P53_PATHWAY0.200Idelalisib— uncovered
APOPTOSIS0.169Idelalisib— uncovered
ALLOGRAFT_REJECTION0.159Idelalisib— uncovered
COAGULATION0.137Binimetinib— uncovered
IL2_STAT5_SIGNALING0.125Idelalisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.125Inavolisib— uncovered
APICAL_SURFACE0.111Temsirolimus— uncovered
HEDGEHOG_SIGNALING0.111Inavolisib— uncovered
ESTROGEN_RESPONSE_EARLY0.108Inavolisib— uncovered