Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · medullo-epn-umap@date-based

88332

EPN · Supratentorial EPN

d06f0e7f-d0e4-5639-858e-3518e3090990

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
EPN
cancer_type_detailed
—
subtype
Supratentorial EPN
cancer_type
EPN
subtype
Supratentorial EPN
age_years
6
fusion
ZFTA_RELA
e1_e2
E2
umap1_2d
-5.178928685
umap2_2d
0.665135469
umap1_3d
0.779581641
umap2_3d
4.064548465
umap3_3d
-0.127756183
dataset
EPN-Felix

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • PROTEIN_SECRETION+0.340
  • BILE_ACID_METABOLISM+0.290
  • HEME_METABOLISM+0.280
  • OXIDATIVE_PHOSPHORYLATION+0.260
  • INTERFERON_GAMMA_RESPONSE+0.240
  • COAGULATION+0.210
  • COMPLEMENT+0.180
  • FATTY_ACID_METABOLISM+0.180
  • PEROXISOME+0.170
  • REACTIVE_OXYGEN_SPECIES_PATHWAY+0.170

Top 10 suppressed

  • G2M_CHECKPOINT-0.470
  • E2F_TARGETS-0.420
  • APICAL_SURFACE-0.400
  • WNT_BETA_CATENIN_SIGNALING-0.390
  • ANGIOGENESIS-0.370
  • MITOTIC_SPINDLE-0.280
  • APICAL_JUNCTION-0.240
  • EPITHELIAL_MESENCHYMAL_TRANSITION-0.230
  • ESTROGEN_RESPONSE_EARLY-0.230
  • ESTROGEN_RESPONSE_LATE-0.200

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

8 twins match this tumor's tissue · 2 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-44-2655-01A-01R-0946-07
lung-landscapes@6
—cohortA20.780
2TCGA-05-5423-01A-01R-1628-07
lung-landscapes@6
—cohortA10.775
3131536
medullo-epn-umap@date-based
EPNEPN Tumor0.774
4TCGA-OR-A5J6-01
acc-tcga-pancan-2018@2018
Adrenocortical CarcinomaAdrenocortical Carcinoma, Usual Type0.757
5TCGA-50-5068-01A-01R-1628-07
lung-landscapes@6
—cohortA10.757
6TCGA-67-3770-01A-01R-0946-07
lung-landscapes@6
—cohortA10.734
7TCGA-5N-A9KM-01A-11R-A42T-07
bladder-landscape@3
——0.723
8SJEPD030146_D1.RNA-Seq
medullo-epn-umap@date-based
EPNSupratentorial EPN0.719
9ERR2598340
medullo-epn-umap@date-based
fetalfetal0.716
10X3cd3fbb2.8eb1.4fd0.ae5f.c940ae00e311
lung-landscapes@6
—cohortA10.715

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 22 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
PROTEIN_SECRETION0.340Remibrutinib— uncovered
BILE_ACID_METABOLISM0.290Inavolisib— uncovered
HEME_METABOLISM0.280Temsirolimus— uncovered
OXIDATIVE_PHOSPHORYLATION0.260Remibrutinib— uncovered
INTERFERON_GAMMA_RESPONSE0.240Idelalisib— uncovered
COAGULATION0.210Binimetinib— uncovered
COMPLEMENT0.180Inavolisib— uncovered
FATTY_ACID_METABOLISM0.180Inavolisib— uncovered
PEROXISOME0.170Idelalisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.170Inavolisib— uncovered
DNA_REPAIR0.160Idelalisib— uncovered
ALLOGRAFT_REJECTION0.150Idelalisib— uncovered
INTERFERON_ALPHA_RESPONSE0.150Inavolisib— uncovered
TGF_BETA_SIGNALING0.150Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.140Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.140Idelalisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.140Inavolisib— uncovered
XENOBIOTIC_METABOLISM0.120Inavolisib— uncovered
P53_PATHWAY0.070Idelalisib— uncovered
KRAS_SIGNALING_UP0.060Inavolisib— uncovered