Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

SRR8613760

· E

d21c4be0-235e-5b5f-8954-48dac47d9193

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
E
subtype
E

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

7 twins match this tumor's tissue · 3 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-85-8350-01A-11R-2296-07
lung-landscapes@6
cohortSQ10.906
2SRR8613753
breast-umap@18
C0.880
3MNG705
mng-umap@100
0.835
4BS_SD8YBRBR
brain-umap@2
high-grade glioma0.833
5a2a777ef-9294-4acf-b489-27bc17272b5e
colon-landscapes@1
0.830
6TCGA-4H-AAAK-01A-12R-A41B-07
breast-umap@18
A0.826
7BS_44A3ES23
medullo-epn-umap@date-based
MedMedulloblastoma0.824
8R7
bladder-landscape@3
0.815
9BS_YK6VQ9SJ
brain-umap@2
DNET0.813
10GSM6454752
breast-umap@18
E0.809

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 19 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
MYOGENESIS0.360Inavolisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.350Inavolisib— uncovered
APICAL_JUNCTION0.320Inavolisib— uncovered
KRAS_SIGNALING_DN0.320Remibrutinib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.310Inavolisib— uncovered
MYC_TARGETS_V20.300Idelalisib— uncovered
HYPOXIA0.290Idelalisib— uncovered
HEDGEHOG_SIGNALING0.280Inavolisib— uncovered
ANGIOGENESIS0.270Remibrutinib— uncovered
NOTCH_SIGNALING0.140Inavolisib— uncovered
COAGULATION0.120Binimetinib— uncovered
MITOTIC_SPINDLE0.120Inavolisib— uncovered
PANCREAS_BETA_CELLS0.100Cobimetinib— uncovered
ESTROGEN_RESPONSE_EARLY0.090Inavolisib— uncovered
APICAL_SURFACE0.080Temsirolimus— uncovered
ESTROGEN_RESPONSE_LATE0.070Idelalisib— uncovered
TGF_BETA_SIGNALING0.030Inavolisib— uncovered
UV_RESPONSE_DN0.030Inavolisib— uncovered
GLYCOLYSIS0.020Inavolisib— uncovered