Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · breast-umap@18

SRR35579803

— · E

d39d7b8b-6c2d-5fc3-9a78-3426381fe7d9

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
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cancer_type_detailed
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subtype
E
subtype
E

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-22-5482-01A-01R-1635-07
lung-landscapes@6
—cohortSQ20.885
2C3L-00081
lung-landscapes@6
—cohortSQ20.884
3TCGA-43-A474-01A-11R-A24H-07
lung-landscapes@6
—cohortSQ20.882
4MNG1297
mng-umap@100
——0.879
5TCGA-B6-A0RU-01A-11R-A084-07
breast-umap@18
—E0.870
6TCGA-85-6798-01A-11R-1949-07
lung-landscapes@6
—cohortSQ20.857
7TCGA-GU-A42Q-01A-11R-A23W-07
bladder-landscape@3
——0.855
8TCGA-92-7341-01A-31R-2045-07
lung-landscapes@6
—cohortSQ20.853
9R156
bladder-landscape@3
——0.852
10SRR8943009
bladder-landscape@3
——0.847

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 35 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
E2F_TARGETS0.590Inavolisib— uncovered
MYC_TARGETS_V10.540Inavolisib— uncovered
G2M_CHECKPOINT0.510Inavolisib— uncovered
MYC_TARGETS_V20.460Idelalisib— uncovered
MTORC1_SIGNALING0.450Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.420Inavolisib— uncovered
ANGIOGENESIS0.410Remibrutinib— uncovered
GLYCOLYSIS0.410Inavolisib— uncovered
HYPOXIA0.410Idelalisib— uncovered
TGF_BETA_SIGNALING0.400Inavolisib— uncovered
SPERMATOGENESIS0.370Inavolisib— uncovered
MITOTIC_SPINDLE0.340Inavolisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.330Inavolisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.280Idelalisib— uncovered
PANCREAS_BETA_CELLS0.270Cobimetinib— uncovered
WNT_BETA_CATENIN_SIGNALING0.260Inavolisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.220Remibrutinib— uncovered
DNA_REPAIR0.220Idelalisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.220Remibrutinib— uncovered
ANDROGEN_RESPONSE0.210Inavolisib— uncovered