Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-B6-A0RM-01A-11R-A084-07

· B

d48b717a-a609-5aa9-95a7-96b5a5d54d53

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
B
subtype
B
overall_survival_months
79

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • MYOGENESIS+0.470
  • MYC_TARGETS_V2+0.410
  • MYC_TARGETS_V1+0.330
  • OXIDATIVE_PHOSPHORYLATION+0.290
  • ESTROGEN_RESPONSE_EARLY+0.260
  • ADIPOGENESIS+0.240
  • DNA_REPAIR+0.240
  • PEROXISOME+0.190
  • FATTY_ACID_METABOLISM+0.180
  • E2F_TARGETS+0.170

Top 10 suppressed

  • INTERFERON_GAMMA_RESPONSE-0.550
  • EPITHELIAL_MESENCHYMAL_TRANSITION-0.520
  • ALLOGRAFT_REJECTION-0.500
  • INTERFERON_ALPHA_RESPONSE-0.500
  • KRAS_SIGNALING_UP-0.480
  • ANGIOGENESIS-0.470
  • INFLAMMATORY_RESPONSE-0.460
  • TNFA_SIGNALING_VIA_NFKB-0.450
  • COMPLEMENT-0.420
  • CHOLESTEROL_HOMEOSTASIS-0.410

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

9 twins match this tumor's tissue · 1 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-S3-AA12-01A-11R-A41B-07
breast-umap@18
B0.871
2TCGA-F7-A61V-01A-11R-A28V-07
head-neck@1
0.859
3R16
bladder-landscape@3
0.837
4BS_NKEAAFMW
brain-umap@2
medulloblastoma0.835
5TCGA-AC-A6NO-01A-12R-A33J-07
breast-umap@18
B0.834
6TCGA-EW-A1P6-01A-11R-A144-07
breast-umap@18
A0.833
7BSR_15_0056_E1_S102
breast-umap@18
B0.828
8TCGA-B6-A0IC-01A-11R-A034-07
breast-umap@18
B0.827
920120289.LumB
breast-umap@18
B0.826
10TCGA-BH-A0H0-01A-11R-A056-07
breast-umap@18
B0.823

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 18 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
MYOGENESIS0.470Inavolisib— uncovered
MYC_TARGETS_V20.410Idelalisib— uncovered
MYC_TARGETS_V10.330Inavolisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.290Remibrutinib— uncovered
ESTROGEN_RESPONSE_EARLY0.260Inavolisib— uncovered
ADIPOGENESIS0.240Inavolisib— uncovered
DNA_REPAIR0.240Idelalisib— uncovered
PEROXISOME0.190Idelalisib— uncovered
FATTY_ACID_METABOLISM0.180Inavolisib— uncovered
E2F_TARGETS0.170Inavolisib— uncovered
G2M_CHECKPOINT0.120Inavolisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.120Idelalisib— uncovered
ESTROGEN_RESPONSE_LATE0.100Idelalisib— uncovered
HEME_METABOLISM0.070Temsirolimus— uncovered
BILE_ACID_METABOLISM0.040Inavolisib— uncovered
KRAS_SIGNALING_DN0.030Remibrutinib— uncovered
SPERMATOGENESIS0.030Inavolisib— uncovered
MITOTIC_SPINDLE0.020Inavolisib— uncovered