SRR659412
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- DNA_REPAIR+0.163
- OXIDATIVE_PHOSPHORYLATION+0.144
- PROTEIN_SECRETION+0.142
- MYC_TARGETS_V2+0.050
- MYC_TARGETS_V1+0.047
- MYOGENESIS+0.047
- KRAS_SIGNALING_DN+0.045
- HEME_METABOLISM+0.016
- PEROXISOME+0.000
- UNFOLDED_PROTEIN_RESPONSE-0.008
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.566
- TNFA_SIGNALING_VIA_NFKB-0.548
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.516
- ANGIOGENESIS-0.515
- INFLAMMATORY_RESPONSE-0.510
- IL6_JAK_STAT3_SIGNALING-0.509
- COAGULATION-0.485
- INTERFERON_GAMMA_RESPONSE-0.478
- KRAS_SIGNALING_UP-0.453
- ALLOGRAFT_REJECTION-0.429
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1360038 | GTEX | — | 0.981 |
| 2 | SRR612419 | GTEX | — | 0.978 |
| 3 | SRR1490568 | GTEX | — | 0.978 |
| 4 | SRR1499442 | GTEX | — | 0.978 |
| 5 | SRR1471417 | GTEX | — | 0.976 |
| 6 | SRR613366 | GTEX | — | 0.976 |
| 7 | SRR1500537 | GTEX | — | 0.976 |
| 8 | SRR1359367 | GTEX | — | 0.976 |
| 9 | SRR1374246 | GTEX | — | 0.974 |
| 10 | SRR1394450 | GTEX | — | 0.974 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 8 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| DNA_REPAIR | 0.163 | Idelalisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.144 | Remibrutinib | — uncovered |
| PROTEIN_SECRETION | 0.142 | Remibrutinib | — uncovered |
| MYC_TARGETS_V2 | 0.050 | Idelalisib | — uncovered |
| MYC_TARGETS_V1 | 0.047 | Inavolisib | — uncovered |
| MYOGENESIS | 0.047 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.045 | Remibrutinib | — uncovered |
| HEME_METABOLISM | 0.016 | Temsirolimus | — uncovered |