Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-E9-A1N6-01A-11R-A144-07

· C

d81e06d5-d348-554e-87cb-be021784e825

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
C
subtype
C
overall_survival_months
23

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • EPITHELIAL_MESENCHYMAL_TRANSITION+0.550
  • CHOLESTEROL_HOMEOSTASIS+0.500
  • MTORC1_SIGNALING+0.450
  • G2M_CHECKPOINT+0.440
  • E2F_TARGETS+0.430
  • ANGIOGENESIS+0.420
  • MITOTIC_SPINDLE+0.350
  • UV_RESPONSE_UP+0.330
  • TGF_BETA_SIGNALING+0.320
  • MYC_TARGETS_V1+0.300

Top 10 suppressed

  • ALLOGRAFT_REJECTION-0.220
  • IL6_JAK_STAT3_SIGNALING-0.220
  • KRAS_SIGNALING_DN-0.170
  • INTERFERON_GAMMA_RESPONSE-0.140
  • INTERFERON_ALPHA_RESPONSE-0.050
  • INFLAMMATORY_RESPONSE-0.030
  • KRAS_SIGNALING_UP-0.030
  • HEME_METABOLISM-0.020
  • SPERMATOGENESIS-0.020
  • MYOGENESIS+0.020

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-68-7756-01A-11R-2125-07
lung-landscapes@6
cohortSQ10.852
2SRR17866829
colon-landscapes@1
0.850
3SRR934967
brain-umap@2
0.844
4SRR8943009
bladder-landscape@3
0.843
55282B52E-8573-4FC0-9BED-420AE3D2B096
brain-umap@2
0.841
6MNG252
mng-umap@100
0.840
7TCGA-77-7337-01A-21R-2045-07
lung-landscapes@6
cohortSQ10.837
8TCGA-FD-A6TH-01A-11R-A32O-07
bladder-landscape@3
0.832
9TCGA-55-6975-01A-11R-1949-07
lung-landscapes@6
cohortA40.828
10DRR168536
bladder-landscape@3
0.815

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 41 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
EPITHELIAL_MESENCHYMAL_TRANSITION0.550Inavolisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.500Remibrutinib— uncovered
MTORC1_SIGNALING0.450Inavolisib— uncovered
G2M_CHECKPOINT0.440Inavolisib— uncovered
E2F_TARGETS0.430Inavolisib— uncovered
ANGIOGENESIS0.420Remibrutinib— uncovered
MITOTIC_SPINDLE0.350Inavolisib— uncovered
UV_RESPONSE_UP0.330Idelalisib— uncovered
TGF_BETA_SIGNALING0.320Inavolisib— uncovered
MYC_TARGETS_V10.300Inavolisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.290Inavolisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.270Idelalisib— uncovered
ANDROGEN_RESPONSE0.260Inavolisib— uncovered
GLYCOLYSIS0.260Inavolisib— uncovered
APICAL_JUNCTION0.250Inavolisib— uncovered
PROTEIN_SECRETION0.240Remibrutinib— uncovered
MYC_TARGETS_V20.230Idelalisib— uncovered
APOPTOSIS0.210Idelalisib— uncovered
HYPOXIA0.210Idelalisib— uncovered
ESTROGEN_RESPONSE_EARLY0.200Inavolisib— uncovered