Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-D8-A146-01A-31R-A115-07

· A

da8e1846-ea67-5cec-b0f7-887dc590db6b

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
A
subtype
A
overall_survival_months
21

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

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Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-D8-A1JH-01A-11R-A13Q-07
breast-umap@18
A0.919
2TCGA-A1-A0SH-01A-11R-A084-07
breast-umap@18
A0.908
322620634-aa34-4cb5-a37f-5a7b0c47cd0e
colon-landscapes@1
0.905
420020009.LumA
breast-umap@18
A0.897
5TCGA-E9-A1NH-01A-11R-A14D-07
breast-umap@18
A0.892
6TCGA-EW-A1IX-01A-12R-A144-07
breast-umap@18
A0.891
7TCGA-HD-7831-01A-11R-2132-07
head-neck@1
0.873
8SRR8613790
breast-umap@18
A0.871
9TCGA-A2-A0EW-01A-21R-A115-07
breast-umap@18
A0.869
10TCGA-DK-A3IQ-01A-31R-A32Y-07
bladder-landscape@3
0.862

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 27 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
EPITHELIAL_MESENCHYMAL_TRANSITION0.560Inavolisib— uncovered
TGF_BETA_SIGNALING0.460Inavolisib— uncovered
ANGIOGENESIS0.420Remibrutinib— uncovered
UV_RESPONSE_DN0.420Inavolisib— uncovered
APICAL_SURFACE0.380Temsirolimus— uncovered
KRAS_SIGNALING_UP0.310Inavolisib— uncovered
PROTEIN_SECRETION0.310Remibrutinib— uncovered
HEDGEHOG_SIGNALING0.300Inavolisib— uncovered
NOTCH_SIGNALING0.270Inavolisib— uncovered
APICAL_JUNCTION0.260Inavolisib— uncovered
COAGULATION0.250Binimetinib— uncovered
TNFA_SIGNALING_VIA_NFKB0.220Inavolisib— uncovered
ESTROGEN_RESPONSE_EARLY0.210Inavolisib— uncovered
MYOGENESIS0.210Inavolisib— uncovered
COMPLEMENT0.200Inavolisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.200Inavolisib— uncovered
ANDROGEN_RESPONSE0.190Inavolisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.160Remibrutinib— uncovered
APOPTOSIS0.150Idelalisib— uncovered
P53_PATHWAY0.150Idelalisib— uncovered