Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

BS_1TPWFSK6

subependymal giant cell astrocytoma(SEGA)

dbb0b786-a566-54b4-83ba-12a274c1dced

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
subependymal giant cell astrocytoma(SEGA)
cancer_type_detailed
subtype
cancer_type
subependymal giant cell astrocytoma(SEGA)
overall_survival_months
18.85676741130092
age_years
0.934
sex
Male

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • ALLOGRAFT_REJECTION+0.580
  • INTERFERON_GAMMA_RESPONSE+0.571
  • TNFA_SIGNALING_VIA_NFKB+0.560
  • INTERFERON_ALPHA_RESPONSE+0.540
  • IL6_JAK_STAT3_SIGNALING+0.537
  • INFLAMMATORY_RESPONSE+0.533
  • REACTIVE_OXYGEN_SPECIES_PATHWAY+0.516
  • EPITHELIAL_MESENCHYMAL_TRANSITION+0.515
  • HYPOXIA+0.471
  • APOPTOSIS+0.459

Top 10 suppressed

  • MYC_TARGETS_V2-0.557
  • E2F_TARGETS-0.396
  • G2M_CHECKPOINT-0.371
  • WNT_BETA_CATENIN_SIGNALING-0.343
  • DNA_REPAIR-0.334
  • MYC_TARGETS_V1-0.334
  • MITOTIC_SPINDLE-0.160
  • HEDGEHOG_SIGNALING-0.155
  • UNFOLDED_PROTEIN_RESPONSE-0.125
  • SPERMATOGENESIS+0.048

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

3 twins match this tumor's tissue · 7 come from a different tissue of origin ← cross-tissue dominant

#SampleCancer typeSubtypecos similarity
1BS_M4TTKPNR
brain-umap@2
pilocytic astrocytoma0.952
2BS_X16PENSA
brain-umap@2
pilocytic astrocytoma0.943
3BS_T0RKFEKR
brain-umap@2
pilocytic astrocytoma0.933
4sclcM1201764A_S68.txt
lung-landscapes@6
cohortMD20.930
5BS_GWCRMKE6
brain-umap@2
pilocytic astrocytoma0.929
6SRR663693
brain-umap@2
GTEX0.929
7BS_HC5M8JTC
brain-umap@2
low-grade glioma0.924
824d909f2-cdc8-4509-91d5-e18fffcf90eb
colon-landscapes@1
0.924
9MDT-AP-0385
medullo-epn-umap@date-based
MedMedulloblastoma0.919
10BS_3W07B2TG
brain-umap@2
subependymal giant cell astrocytoma(SEGA)0.912

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 41 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
ALLOGRAFT_REJECTION0.580Idelalisib— uncovered
INTERFERON_GAMMA_RESPONSE0.571Idelalisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.560Inavolisib— uncovered
INTERFERON_ALPHA_RESPONSE0.540Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.537Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.533Idelalisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.516Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.515Inavolisib— uncovered
HYPOXIA0.471Idelalisib— uncovered
APOPTOSIS0.459Idelalisib— uncovered
COMPLEMENT0.435Inavolisib— uncovered
COAGULATION0.434Binimetinib— uncovered
MTORC1_SIGNALING0.433Inavolisib— uncovered
PROTEIN_SECRETION0.433Remibrutinib— uncovered
CHOLESTEROL_HOMEOSTASIS0.427Remibrutinib— uncovered
IL2_STAT5_SIGNALING0.414Idelalisib— uncovered
XENOBIOTIC_METABOLISM0.388Inavolisib— uncovered
KRAS_SIGNALING_UP0.384Inavolisib— uncovered
ANDROGEN_RESPONSE0.374Inavolisib— uncovered
ANGIOGENESIS0.363Remibrutinib— uncovered