MBCProject_2741_T1A_RNA
— · C
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- C
- subtype
- C
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- INTERFERON_ALPHA_RESPONSE+0.470
- PROTEIN_SECRETION+0.370
- INTERFERON_GAMMA_RESPONSE+0.350
- E2F_TARGETS+0.340
- MTORC1_SIGNALING+0.330
- OXIDATIVE_PHOSPHORYLATION+0.280
- CHOLESTEROL_HOMEOSTASIS+0.270
- DNA_REPAIR+0.270
- MYC_TARGETS_V1+0.250
- ANDROGEN_RESPONSE+0.220
Top 10 suppressed
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.480
- ANGIOGENESIS-0.460
- HEDGEHOG_SIGNALING-0.460
- PANCREAS_BETA_CELLS-0.400
- WNT_BETA_CATENIN_SIGNALING-0.360
- TGF_BETA_SIGNALING-0.310
- UV_RESPONSE_DN-0.310
- APICAL_JUNCTION-0.280
- MYOGENESIS-0.280
- NOTCH_SIGNALING-0.280
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | 81b828aa-cb06-4790-ba3e-efaa39f4eeef | — | — | 0.848 |
| 2 | TCGA-55-1596-01A-01R-0946-07 | — | cohortA4 | 0.846 |
| 3 | SRR29022827 | — | C | 0.843 |
| 4 | TCGA-A8-A09M-01A-11R-A00Z-07 | — | B | 0.823 |
| 5 | R135 | — | — | 0.820 |
| 6 | TCGA-BH-A0EE-01A-11R-A034-07 | — | C | 0.811 |
| 7 | SRR8942934 | — | — | 0.811 |
| 8 | AUR-ADCB-TTM1-A-1-1-R-A742-41 | — | C | 0.810 |
| 9 | 20070130.TNBC | — | C | 0.807 |
| 10 | SRR17866821 | — | — | 0.806 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 26 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| INTERFERON_ALPHA_RESPONSE | 0.470 | Inavolisib | — uncovered |
| PROTEIN_SECRETION | 0.370 | Remibrutinib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.350 | Idelalisib | — uncovered |
| E2F_TARGETS | 0.340 | Inavolisib | — uncovered |
| MTORC1_SIGNALING | 0.330 | Inavolisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.280 | Remibrutinib | — uncovered |
| CHOLESTEROL_HOMEOSTASIS | 0.270 | Remibrutinib | — uncovered |
| DNA_REPAIR | 0.270 | Idelalisib | — uncovered |
| MYC_TARGETS_V1 | 0.250 | Inavolisib | — uncovered |
| ANDROGEN_RESPONSE | 0.220 | Inavolisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.220 | Inavolisib | — uncovered |
| G2M_CHECKPOINT | 0.220 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.220 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.210 | Inavolisib | — uncovered |
| PEROXISOME | 0.200 | Idelalisib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.200 | Inavolisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.190 | Idelalisib | — uncovered |
| ESTROGEN_RESPONSE_LATE | 0.150 | Idelalisib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.140 | Inavolisib | — uncovered |
| XENOBIOTIC_METABOLISM | 0.140 | Inavolisib | — uncovered |