Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

SRR934870

de19eadd-66d8-5f00-804e-751b5ee1d441

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
80.71616294349539
age_years
33
sex
Female

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • TGF_BETA_SIGNALING+0.504
  • MYC_TARGETS_V1+0.463
  • NOTCH_SIGNALING+0.437
  • MITOTIC_SPINDLE+0.410
  • WNT_BETA_CATENIN_SIGNALING+0.402
  • G2M_CHECKPOINT+0.398
  • PROTEIN_SECRETION+0.290
  • UV_RESPONSE_DN+0.281
  • HEDGEHOG_SIGNALING+0.271
  • DNA_REPAIR+0.252

Top 10 suppressed

  • KRAS_SIGNALING_DN-0.366
  • ANGIOGENESIS-0.270
  • MYOGENESIS-0.265
  • PANCREAS_BETA_CELLS-0.227
  • COAGULATION-0.202
  • EPITHELIAL_MESENCHYMAL_TRANSITION-0.194
  • SPERMATOGENESIS-0.194
  • HYPOXIA-0.185
  • TNFA_SIGNALING_VIA_NFKB-0.114
  • REACTIVE_OXYGEN_SPECIES_PATHWAY-0.090

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR934799
brain-umap@2
0.926
21F4B7E2E-E242-410A-AE78-8FC412D3C0A9
brain-umap@2
0.924
363204446-7AA0-40DC-996D-440F4E19AD0F
brain-umap@2
0.911
4B7B9B5C1-C11D-47B8-B2F8-A5660AB961C1
brain-umap@2
0.910
59198B2FA-637D-44B2-B6E8-24B5681737AA
brain-umap@2
0.909
624F914FE-3DF0-4286-9231-9D525A777306
brain-umap@2
0.909
7SRR934727
brain-umap@2
0.904
8D5E8379B-621C-4551-9B13-E63B1B068488
brain-umap@2
0.899
9F35F85A8-B3CD-4116-990F-94B2E432F902
brain-umap@2
0.899
10SRR934777
brain-umap@2
0.897

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 30 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
TGF_BETA_SIGNALING0.504Inavolisib— uncovered
MYC_TARGETS_V10.463Inavolisib— uncovered
NOTCH_SIGNALING0.437Inavolisib— uncovered
MITOTIC_SPINDLE0.410Inavolisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.402Inavolisib— uncovered
G2M_CHECKPOINT0.398Inavolisib— uncovered
PROTEIN_SECRETION0.290Remibrutinib— uncovered
UV_RESPONSE_DN0.281Inavolisib— uncovered
HEDGEHOG_SIGNALING0.271Inavolisib— uncovered
DNA_REPAIR0.252Idelalisib— uncovered
MYC_TARGETS_V20.244Idelalisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.242Remibrutinib— uncovered
ADIPOGENESIS0.238Inavolisib— uncovered
E2F_TARGETS0.235Inavolisib— uncovered
MTORC1_SIGNALING0.231Inavolisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.230Idelalisib— uncovered
ANDROGEN_RESPONSE0.115Inavolisib— uncovered
HEME_METABOLISM0.104Temsirolimus— uncovered
BILE_ACID_METABOLISM0.099Inavolisib— uncovered
PEROXISOME0.093Idelalisib— uncovered