Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.
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TCGA-DK-A6B1-01A-12R-A30C-07

de65dfb5-38a5-521a-b61f-c719f570542f

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
67.31274639
os_event
false
sex
Male

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

9 twins match this tumor's tissue · 1 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
120040104.LumB
breast-umap@18
B0.853
21ac3f1b2-5b83-470c-b1d3-d35d813f3e65
colon-landscapes@1
0.853
3SRR6013568
lung-landscapes@6
cohortA20.847
4MDT-AP-0395
medullo-epn-umap@date-based
MedMedulloblastoma0.844
5TCGA-AO-A0JI-01A-21R-A056-07
breast-umap@18
B0.843
6df4e44f9-ee22-43d3-911e-fd4bd826ec0c
colon-landscapes@1
0.838
7AUR-AFKB-TTM1-A-1-1-R-A742-41
breast-umap@18
C0.834
820140146.LumB
breast-umap@18
B0.832
9TCGA-B6-A0IC-01A-11R-A034-07
breast-umap@18
B0.832
10DRR168601
bladder-landscape@3
0.820

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 15 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
OXIDATIVE_PHOSPHORYLATION0.360Remibrutinib— uncovered
PEROXISOME0.340Idelalisib— uncovered
PROTEIN_SECRETION0.320Remibrutinib— uncovered
FATTY_ACID_METABOLISM0.300Inavolisib— uncovered
DNA_REPAIR0.260Idelalisib— uncovered
MYC_TARGETS_V10.260Inavolisib— uncovered
E2F_TARGETS0.250Inavolisib— uncovered
BILE_ACID_METABOLISM0.220Inavolisib— uncovered
XENOBIOTIC_METABOLISM0.120Inavolisib— uncovered
HEME_METABOLISM0.110Temsirolimus— uncovered
ADIPOGENESIS0.100Inavolisib— uncovered
ANDROGEN_RESPONSE0.090Inavolisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.040Inavolisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.040Idelalisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.010Remibrutinib— uncovered