Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-IQ-A61G-01A-11R-A30B-07

e1f18e51-7c86-5b03-a4c9-c26aa032b988

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
sex
male

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • OXIDATIVE_PHOSPHORYLATION+0.600
  • MYC_TARGETS_V1+0.590
  • MYC_TARGETS_V2+0.520
  • DNA_REPAIR+0.440
  • E2F_TARGETS+0.420
  • REACTIVE_OXYGEN_SPECIES_PATHWAY+0.370
  • TNFA_SIGNALING_VIA_NFKB+0.370
  • MTORC1_SIGNALING+0.360
  • PANCREAS_BETA_CELLS+0.350
  • G2M_CHECKPOINT+0.290

Top 10 suppressed

  • EPITHELIAL_MESENCHYMAL_TRANSITION-0.470
  • ANGIOGENESIS-0.440
  • HEDGEHOG_SIGNALING-0.430
  • WNT_BETA_CATENIN_SIGNALING-0.400
  • UV_RESPONSE_DN-0.370
  • APICAL_SURFACE-0.360
  • MYOGENESIS-0.330
  • ALLOGRAFT_REJECTION-0.300
  • APICAL_JUNCTION-0.280
  • IL6_JAK_STAT3_SIGNALING-0.280

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
12d83a9e6-da2d-47e1-b2e7-4b07b108f7bd
colon-landscapes@1
0.849
2SRR8518329
breast-umap@18
E0.845
3TCGA-39-5036-01A-01R-1443-07
lung-landscapes@6
cohortSQ20.833
40acddbbc-6b74-4fdd-903d-f5ec9bfd8514
colon-landscapes@1
0.829
579a36f11-38bb-42ed-a95a-ae2a9eea0f6a
colon-landscapes@1
0.828
6TCGA-BB-A5HY-01A-11R-A28V-07
head-neck@1
0.822
7dfb9c45f-cb52-4e36-b663-1a9e8c7c0b47
colon-landscapes@1
0.816
8c6c161fd-9f0a-4ad5-96ba-b9ce811348fc
colon-landscapes@1
0.811
98027196b-a80b-4759-872d-b72c98905451
colon-landscapes@1
0.806
106f2c5313-1c83-46c7-a15c-5b9526c1763b
colon-landscapes@1
0.805

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 22 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
OXIDATIVE_PHOSPHORYLATION0.600Remibrutinib— uncovered
MYC_TARGETS_V10.590Inavolisib— uncovered
MYC_TARGETS_V20.520Idelalisib— uncovered
DNA_REPAIR0.440Idelalisib— uncovered
E2F_TARGETS0.420Inavolisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.370Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.370Inavolisib— uncovered
MTORC1_SIGNALING0.360Inavolisib— uncovered
PANCREAS_BETA_CELLS0.350Cobimetinib— uncovered
G2M_CHECKPOINT0.290Inavolisib— uncovered
GLYCOLYSIS0.290Inavolisib— uncovered
UV_RESPONSE_UP0.290Idelalisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.270Idelalisib— uncovered
FATTY_ACID_METABOLISM0.250Inavolisib— uncovered
P53_PATHWAY0.200Idelalisib— uncovered
PEROXISOME0.190Idelalisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.180Remibrutinib— uncovered
ADIPOGENESIS0.160Inavolisib— uncovered
HYPOXIA0.120Idelalisib— uncovered
SPERMATOGENESIS0.090Inavolisib— uncovered