Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

SRR9879289

· cohortSQ1

e25c3793-bb8f-5f6d-a4f0-e122f44de8c6

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
cohortSQ1
subtype
cohortSQ1

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

5 twins match this tumor's tissue · 5 come from a different tissue of origin ← cross-tissue dominant

#SampleCancer typeSubtypecos similarity
1SRR1317853
brain-umap@2
GTEX0.921
2BS_MQCKXD60
brain-umap@2
Glial-neuronal tumor NOS0.916
3525b66e0-235a-4bf5-bc46-eb022d630115
melanoma-umap@29
0.912
4TCGA-63-A5MG-01A-12R-A27Q-07
lung-landscapes@6
cohortSQ10.910
5X9cad7a78.ea9b.47b0.9d06.e5e696031cc3
lung-landscapes@6
cohortA10.909
6TCGA-49-4512-01A-21R-1858-07
lung-landscapes@6
cohortA10.905
7SRR1487825
brain-umap@2
GTEX0.901
8SRR1390582
brain-umap@2
GTEX0.899
9SRR1378155
brain-umap@2
GTEX0.898
10TCGA-95-A4VP-01A-21R-A262-07
lung-landscapes@6
cohortA30.895

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 20 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
EPITHELIAL_MESENCHYMAL_TRANSITION0.510Inavolisib— uncovered
ANGIOGENESIS0.430Remibrutinib— uncovered
PANCREAS_BETA_CELLS0.430Cobimetinib— uncovered
KRAS_SIGNALING_DN0.420Remibrutinib— uncovered
COAGULATION0.400Binimetinib— uncovered
MYOGENESIS0.280Inavolisib— uncovered
HEDGEHOG_SIGNALING0.270Inavolisib— uncovered
APICAL_SURFACE0.260Temsirolimus— uncovered
KRAS_SIGNALING_UP0.240Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.240Inavolisib— uncovered
NOTCH_SIGNALING0.200Inavolisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.200Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.170Idelalisib— uncovered
P53_PATHWAY0.170Idelalisib— uncovered
APICAL_JUNCTION0.160Inavolisib— uncovered
HYPOXIA0.120Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.110Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.100Idelalisib— uncovered
IL2_STAT5_SIGNALING0.040Idelalisib— uncovered
ESTROGEN_RESPONSE_EARLY0.010Inavolisib— uncovered