Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

SRR1797301

· cohortMD2

e3092f9e-9e45-5c29-9720-9dbc71fa9d9b

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
cohortMD2
subtype
cohortMD2
age_years
56

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

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Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

4 twins match this tumor's tissue · 6 come from a different tissue of origin ← cross-tissue dominant

#SampleCancer typeSubtypecos similarity
1TCGA-MS-A51U-01A-31R-A266-07
breast-umap@18
A0.803
2SRR612575
brain-umap@2
GTEX0.778
3BS_E2Z940S4
brain-umap@2
Meningioma0.778
4SRR1313091
breast-umap@18
A0.776
5BS_NPQJ20KX
brain-umap@2
pilocytic astrocytoma0.770
6SRR1400245
brain-umap@2
GTEX0.768
7SRR1072178
brain-umap@2
GTEX0.764
8BS_TXY8QYWA
medullo-epn-umap@date-based
EPNPosterior Fossa EPN0.762
9BSR_15_0097_A4_S88
breast-umap@18
A0.760
1069d9a82b-5c37-45bd-a1cf-ffe1392e84fc
melanoma-umap@29
0.756

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 27 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
EPITHELIAL_MESENCHYMAL_TRANSITION0.400Inavolisib— uncovered
APICAL_SURFACE0.310Temsirolimus— uncovered
UV_RESPONSE_DN0.310Inavolisib— uncovered
COAGULATION0.270Binimetinib— uncovered
APICAL_JUNCTION0.240Inavolisib— uncovered
ESTROGEN_RESPONSE_EARLY0.240Inavolisib— uncovered
NOTCH_SIGNALING0.240Inavolisib— uncovered
MYOGENESIS0.230Inavolisib— uncovered
P53_PATHWAY0.230Idelalisib— uncovered
XENOBIOTIC_METABOLISM0.140Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.120Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.110Inavolisib— uncovered
APOPTOSIS0.100Idelalisib— uncovered
ESTROGEN_RESPONSE_LATE0.100Idelalisib— uncovered
BILE_ACID_METABOLISM0.090Inavolisib— uncovered
ADIPOGENESIS0.080Inavolisib— uncovered
FATTY_ACID_METABOLISM0.070Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.050Idelalisib— uncovered
KRAS_SIGNALING_DN0.050Remibrutinib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.050Inavolisib— uncovered