Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.
KIRhub 2.0
Sign in

7f51ff28-397d-466f-82b0-25e9c9182ea7

e455b477-6670-563c-9123-784f779f8cb5

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • COAGULATION+0.500
  • EPITHELIAL_MESENCHYMAL_TRANSITION+0.500
  • IL6_JAK_STAT3_SIGNALING+0.500
  • ALLOGRAFT_REJECTION+0.400
  • ANGIOGENESIS+0.400
  • APICAL_JUNCTION+0.400
  • COMPLEMENT+0.400
  • INFLAMMATORY_RESPONSE+0.400
  • MYOGENESIS+0.400
  • NOTCH_SIGNALING+0.400

Top 10 suppressed

  • E2F_TARGETS-0.700
  • G2M_CHECKPOINT-0.600
  • MYC_TARGETS_V1-0.600
  • PROTEIN_SECRETION-0.500
  • OXIDATIVE_PHOSPHORYLATION-0.400
  • UNFOLDED_PROTEIN_RESPONSE-0.400
  • MTORC1_SIGNALING-0.300
  • MYC_TARGETS_V2-0.300
  • ANDROGEN_RESPONSE-0.200
  • DNA_REPAIR-0.200

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

6 twins match this tumor's tissue · 4 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR2689710
melanoma-umap@29
0.951
2BS_TA9WP4TH
medullo-epn-umap@date-based
MedMedulloblastoma0.936
3MDT-AP-1125
medullo-epn-umap@date-based
MedMedulloblastoma0.936
49b308588-5e79-46ab-b186-6edd686695c6
colon-landscapes@1
0.936
5SAMN03290902
melanoma-umap@29
0.933
6R52
bladder-landscape@3
0.932
7R89
bladder-landscape@3
0.928
8BS_ZV9Z3SY6
brain-umap@2
pilocytic astrocytoma0.920
9MDT-AP-0384
medullo-epn-umap@date-based
MedMedulloblastoma0.917
10TCGA-A2-A0CO-01A-13R-A22K-07
breast-umap@18
A0.916