Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-XF-A9SU-01A-31R-A39I-07

e45a6a3d-eea0-584e-8f08-91217a2ffe0f

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
5.978975033
os_event
true
sex
Female

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

9 twins match this tumor's tissue · 1 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1MNG589
mng-umap@100
0.845
2TCGA-AN-A0FT-01A-11R-A034-07
breast-umap@18
B0.830
309f758e5-6be1-4f29-ac92-869d92f8fbcf
melanoma-umap@29
0.789
4773b41d4-8c43-4777-99b8-190c7e7793e0
melanoma-umap@29
0.781
5TCGA-60-2720-01A-01R-0851-07
lung-landscapes@6
cohortSQ10.781
6TCGA-85-A4JC-01A-11R-A24Z-07
lung-landscapes@6
cohortSQ10.761
7b9189c77-004e-461a-9c15-b504b12a3030
colon-landscapes@1
0.751
8MDT-AP-2372
medullo-epn-umap@date-based
MedMedulloblastoma0.749
9SAMN03290888
melanoma-umap@29
0.748
109a4f9e4a-dc97-4f8d-9075-537b62fb98d3
melanoma-umap@29
0.743

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 30 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
EPITHELIAL_MESENCHYMAL_TRANSITION0.560Inavolisib— uncovered
ANGIOGENESIS0.430Remibrutinib— uncovered
COAGULATION0.410Binimetinib— uncovered
MYOGENESIS0.410Inavolisib— uncovered
APICAL_SURFACE0.360Temsirolimus— uncovered
MYC_TARGETS_V20.330Idelalisib— uncovered
APICAL_JUNCTION0.300Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.280Idelalisib— uncovered
ALLOGRAFT_REJECTION0.260Idelalisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.230Remibrutinib— uncovered
KRAS_SIGNALING_UP0.220Inavolisib— uncovered
PANCREAS_BETA_CELLS0.220Cobimetinib— uncovered
CHOLESTEROL_HOMEOSTASIS0.210Remibrutinib— uncovered
NOTCH_SIGNALING0.210Inavolisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.200Inavolisib— uncovered
IL2_STAT5_SIGNALING0.190Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.190Inavolisib— uncovered
DNA_REPAIR0.160Idelalisib— uncovered
UV_RESPONSE_UP0.160Idelalisib— uncovered
XENOBIOTIC_METABOLISM0.140Inavolisib— uncovered