Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · breast-umap@18

SRR8613735

— · E

e514b202-1303-551b-8ad7-7a9c7f11acee

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
—
cancer_type_detailed
—
subtype
E
subtype
E

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • G2M_CHECKPOINT+0.540
  • E2F_TARGETS+0.480
  • MITOTIC_SPINDLE+0.440
  • MYC_TARGETS_V1+0.330
  • EPITHELIAL_MESENCHYMAL_TRANSITION+0.320
  • WNT_BETA_CATENIN_SIGNALING+0.310
  • TGF_BETA_SIGNALING+0.300
  • TNFA_SIGNALING_VIA_NFKB+0.300
  • NOTCH_SIGNALING+0.260
  • MYC_TARGETS_V2+0.250

Top 10 suppressed

  • INTERFERON_ALPHA_RESPONSE-0.380
  • BILE_ACID_METABOLISM-0.250
  • INTERFERON_GAMMA_RESPONSE-0.230
  • ALLOGRAFT_REJECTION-0.180
  • COAGULATION-0.180
  • FATTY_ACID_METABOLISM-0.180
  • OXIDATIVE_PHOSPHORYLATION-0.180
  • XENOBIOTIC_METABOLISM-0.180
  • CHOLESTEROL_HOMEOSTASIS-0.170
  • COMPLEMENT-0.150

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

6 twins match this tumor's tissue · 4 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR8613747
breast-umap@18
—D0.850
2ERR2598207
medullo-epn-umap@date-based
fetalfetal0.850
3TCGA-D8-A27F-01A-11R-A16F-07
breast-umap@18
—E0.836
4TCGA-21-A5DI-01A-31R-A26W-07
lung-landscapes@6
—cohortSQ10.824
5TCGA-58-8390-01A-11R-2326-07
lung-landscapes@6
—cohortSQ10.821
6ERR2598171
medullo-epn-umap@date-based
fetalfetal0.804
7ERR2598166
medullo-epn-umap@date-based
fetalfetal0.804
8TCGA-60-2703-01A-11R-2045-07
lung-landscapes@6
—cohortSQ10.804
9TCGA-21-5783-01A-41R-2187-07
lung-landscapes@6
—cohortMD10.799
10ERR2598184
medullo-epn-umap@date-based
fetalfetal0.794

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 28 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
G2M_CHECKPOINT0.540Inavolisib— uncovered
E2F_TARGETS0.480Inavolisib— uncovered
MITOTIC_SPINDLE0.440Inavolisib— uncovered
MYC_TARGETS_V10.330Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.320Inavolisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.310Inavolisib— uncovered
TGF_BETA_SIGNALING0.300Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.300Inavolisib— uncovered
NOTCH_SIGNALING0.260Inavolisib— uncovered
MYC_TARGETS_V20.250Idelalisib— uncovered
UV_RESPONSE_DN0.240Inavolisib— uncovered
MTORC1_SIGNALING0.210Inavolisib— uncovered
UV_RESPONSE_UP0.200Idelalisib— uncovered
ANGIOGENESIS0.190Remibrutinib— uncovered
APICAL_JUNCTION0.190Inavolisib— uncovered
GLYCOLYSIS0.170Inavolisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.150Idelalisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.120Inavolisib— uncovered
HYPOXIA0.100Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.100Inavolisib— uncovered