Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

BS_JBGZ7HHZ

ganglioneuroblastoma

e5c256f6-9552-50ee-9a7c-e4ce12af55cc

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
ganglioneuroblastoma
cancer_type_detailed
subtype
cancer_type
ganglioneuroblastoma
overall_survival_months
41.49145860709592
age_years
4.567
sex
Female

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • INTERFERON_ALPHA_RESPONSE+0.635
  • ALLOGRAFT_REJECTION+0.613
  • INTERFERON_GAMMA_RESPONSE+0.606
  • INFLAMMATORY_RESPONSE+0.515
  • IL6_JAK_STAT3_SIGNALING+0.512
  • ANGIOGENESIS+0.472
  • COAGULATION+0.466
  • EPITHELIAL_MESENCHYMAL_TRANSITION+0.438
  • COMPLEMENT+0.427
  • APICAL_SURFACE+0.414

Top 10 suppressed

  • MYC_TARGETS_V2-0.423
  • MTORC1_SIGNALING-0.410
  • OXIDATIVE_PHOSPHORYLATION-0.383
  • CHOLESTEROL_HOMEOSTASIS-0.366
  • MYC_TARGETS_V1-0.357
  • UNFOLDED_PROTEIN_RESPONSE-0.295
  • PROTEIN_SECRETION-0.285
  • ADIPOGENESIS-0.246
  • E2F_TARGETS-0.233
  • GLYCOLYSIS-0.230

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

5 twins match this tumor's tissue · 5 come from a different tissue of origin ← cross-tissue dominant

#SampleCancer typeSubtypecos similarity
1SRR821602
brain-umap@2
GTEX0.926
2e5b29c06-2ed0-4913-bf24-5bfde047defc
melanoma-umap@29
0.925
3MNG303
mng-umap@100
0.912
4TCGA-55-6979-01A-11R-1949-07
lung-landscapes@6
cohortA10.909
5BS_FRM9TG02
brain-umap@2
Neurofibroma0.905
6TCGA-MP-A4TI-01A-21R-A24X-07
lung-landscapes@6
cohortA10.904
7SRR599510
brain-umap@2
GTEX0.900
8TCGA-55-8299-01A-11R-2287-07
lung-landscapes@6
cohortMD20.900
9MDT-AP-0363
medullo-epn-umap@date-based
MedMedulloblastoma0.898
10MDT-AP-1177
medullo-epn-umap@date-based
MedMedulloblastoma0.896

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 26 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
INTERFERON_ALPHA_RESPONSE0.635Inavolisib— uncovered
ALLOGRAFT_REJECTION0.613Idelalisib— uncovered
INTERFERON_GAMMA_RESPONSE0.606Idelalisib— uncovered
INFLAMMATORY_RESPONSE0.515Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.512Inavolisib— uncovered
ANGIOGENESIS0.472Remibrutinib— uncovered
COAGULATION0.466Binimetinib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.438Inavolisib— uncovered
COMPLEMENT0.427Inavolisib— uncovered
APICAL_SURFACE0.414Temsirolimus— uncovered
TNFA_SIGNALING_VIA_NFKB0.395Inavolisib— uncovered
KRAS_SIGNALING_UP0.376Inavolisib— uncovered
IL2_STAT5_SIGNALING0.331Idelalisib— uncovered
APOPTOSIS0.295Idelalisib— uncovered
APICAL_JUNCTION0.208Inavolisib— uncovered
MYOGENESIS0.148Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.138Idelalisib— uncovered
KRAS_SIGNALING_DN0.098Remibrutinib— uncovered
P53_PATHWAY0.087Idelalisib— uncovered
TGF_BETA_SIGNALING0.087Inavolisib— uncovered