SRR1378004
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- KRAS_SIGNALING_DN+0.367
- PANCREAS_BETA_CELLS+0.359
- BILE_ACID_METABOLISM+0.254
- HEDGEHOG_SIGNALING+0.243
- FATTY_ACID_METABOLISM+0.145
- SPERMATOGENESIS+0.115
- ESTROGEN_RESPONSE_LATE+0.083
- OXIDATIVE_PHOSPHORYLATION+0.070
- MYOGENESIS+0.032
- XENOBIOTIC_METABOLISM+0.026
Top 10 suppressed
- MYC_TARGETS_V2-0.543
- E2F_TARGETS-0.502
- G2M_CHECKPOINT-0.488
- MYC_TARGETS_V1-0.487
- UNFOLDED_PROTEIN_RESPONSE-0.457
- INTERFERON_ALPHA_RESPONSE-0.443
- DNA_REPAIR-0.423
- PROTEIN_SECRETION-0.405
- INTERFERON_GAMMA_RESPONSE-0.373
- IL6_JAK_STAT3_SIGNALING-0.333
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
8 twins match this tumor's tissue · 2 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1474333 | GTEX | — | 0.945 |
| 2 | SRR1354910 | GTEX | — | 0.945 |
| 3 | SRR1336158 | GTEX | — | 0.930 |
| 4 | SRR1498640 | GTEX | — | 0.929 |
| 5 | BS_WCRKYV0T | low-grade glioma | — | 0.927 |
| 6 | BS_DMZP9G1H | Ganglioglioma | — | 0.921 |
| 7 | SRR1405007 | GTEX | — | 0.919 |
| 8 | SRR1433431 | GTEX | — | 0.918 |
| 9 | SRR1409282 | GTEX | — | 0.918 |
| 10 | SRR1408368 | GTEX | — | 0.916 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 10 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| KRAS_SIGNALING_DN | 0.367 | Remibrutinib | — uncovered |
| PANCREAS_BETA_CELLS | 0.359 | Cobimetinib | — uncovered |
| BILE_ACID_METABOLISM | 0.254 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.243 | Inavolisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.145 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.115 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_LATE | 0.083 | Idelalisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.070 | Remibrutinib | — uncovered |
| MYOGENESIS | 0.032 | Inavolisib | — uncovered |
| XENOBIOTIC_METABOLISM | 0.026 | Inavolisib | — uncovered |