BS_8ZP3CBQA

EPN · Posterior Fossa EPN

e7205d0c-62da-5eca-b0bc-720ee53db982

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type: EPN
cancer_type_detailed: —
subtype: Posterior Fossa EPN
cancer_type: EPN
subtype: Posterior Fossa EPN
overall_survival_months: 15.600000000000001
os_event: false
age_years: 5.132
sex: F
e1_e2: E2
umap1_2d: -5.530785024
umap2_2d: -0.012874273
umap1_3d: -0.313529374
umap2_3d: 3.000165533
umap3_3d: 0.597808263
dataset: EPN-CBTN

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

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Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

7 twins match this tumor's tissue · 3 come from a different tissue of origin

#	Sample	Cancer type	Subtype	cos similarity
1	BS_3DCBDJAT brain-umap@2	Meningioma	—	0.772
2	TCGA-H7-A6C4-01A-11R-A30B-07 head-neck@1	—	—	0.770
3	841ae9cb-ae41-46f9-84ae-03c99fd4e6dd colon-landscapes@1	—	—	0.765
4	SRR5088904 melanoma-umap@29	—	—	0.764
5	BS_JHGW42S6 medullo-epn-umap@date-based	EPN	Posterior Fossa EPN	0.758
6	b1dde645-b48d-44e0-9fe0-2af02470ffb5 colon-landscapes@1	—	—	0.758
7	cc158c27-a2f0-4403-ae01-913bfcc623cc colon-landscapes@1	—	—	0.756
8	BS_JHGW42S6 brain-umap@2	Posterior Fossa Ependymoma	—	0.751
9	SAMN03290935 melanoma-umap@29	—	—	0.750
10	BS_NDC69214 brain-umap@2	Neurofibroma	—	0.748

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 32 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)	tumor score	Best drug	reversal magnitude
EPITHELIAL_MESENCHYMAL_TRANSITION	0.470	Inavolisib	— uncovered
MYOGENESIS	0.390	Inavolisib	— uncovered
HYPOXIA	0.360	Idelalisib	— uncovered
IL6_JAK_STAT3_SIGNALING	0.340	Inavolisib	— uncovered
COAGULATION	0.330	Binimetinib	— uncovered
APICAL_JUNCTION	0.260	Inavolisib	— uncovered
COMPLEMENT	0.260	Inavolisib	— uncovered
GLYCOLYSIS	0.250	Inavolisib	— uncovered
INTERFERON_GAMMA_RESPONSE	0.230	Idelalisib	— uncovered
INFLAMMATORY_RESPONSE	0.210	Idelalisib	— uncovered
TNFA_SIGNALING_VIA_NFKB	0.210	Inavolisib	— uncovered
KRAS_SIGNALING_DN	0.200	Remibrutinib	— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY	0.200	Inavolisib	— uncovered
UV_RESPONSE_DN	0.180	Inavolisib	— uncovered
ALLOGRAFT_REJECTION	0.150	Idelalisib	— uncovered
OXIDATIVE_PHOSPHORYLATION	0.130	Remibrutinib	— uncovered
P53_PATHWAY	0.130	Idelalisib	— uncovered
APOPTOSIS	0.120	Idelalisib	— uncovered
ESTROGEN_RESPONSE_EARLY	0.120	Inavolisib	— uncovered
IL2_STAT5_SIGNALING	0.120	Idelalisib	— uncovered