Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

BS_F8N6CFQE

low-grade glioma

e7b9cfe5-087a-5343-b262-eb3e6fde4b16

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
low-grade glioma
cancer_type_detailed
subtype
cancer_type
low-grade glioma
overall_survival_months
22.536136662286463
age_years
3.208
sex
Male

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

5 twins match this tumor's tissue · 5 come from a different tissue of origin ← cross-tissue dominant

#SampleCancer typeSubtypecos similarity
1BS_014EVM2D
brain-umap@2
low-grade glioma0.968
2BS_V89HGTET
brain-umap@2
pilocytic astrocytoma0.960
3BS_MF9X3PKH
brain-umap@2
low-grade glioma0.955
4BS_JWSR581E
brain-umap@2
low-grade glioma0.949
5BS_S4V9E1XJ
brain-umap@2
pilocytic astrocytoma0.943
6BS_QRNSKFMS
brain-umap@2
pilocytic astrocytoma0.942
7BS_Q79NP5YY
brain-umap@2
pilocytic astrocytoma0.942
8BS_55JW3HFM
brain-umap@2
Ganglioglioma0.940
9BS_52426AMF
brain-umap@2
low-grade glioma0.940
10BS_S7CZY2CH
brain-umap@2
low-grade glioma0.938

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 38 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
IL6_JAK_STAT3_SIGNALING0.532Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.526Idelalisib— uncovered
INTERFERON_ALPHA_RESPONSE0.498Inavolisib— uncovered
ALLOGRAFT_REJECTION0.473Idelalisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.451Inavolisib— uncovered
PROTEIN_SECRETION0.449Remibrutinib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.447Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.442Idelalisib— uncovered
COMPLEMENT0.436Inavolisib— uncovered
ANGIOGENESIS0.420Remibrutinib— uncovered
IL2_STAT5_SIGNALING0.416Idelalisib— uncovered
ANDROGEN_RESPONSE0.385Inavolisib— uncovered
TGF_BETA_SIGNALING0.377Inavolisib— uncovered
COAGULATION0.370Binimetinib— uncovered
KRAS_SIGNALING_UP0.350Inavolisib— uncovered
UV_RESPONSE_DN0.350Inavolisib— uncovered
APOPTOSIS0.331Idelalisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.329Remibrutinib— uncovered
HEDGEHOG_SIGNALING0.246Inavolisib— uncovered
ESTROGEN_RESPONSE_EARLY0.238Inavolisib— uncovered