MNG79

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e8dc2201-ed88-5f2a-8b71-725593d664d3

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type: —
cancer_type_detailed: —
subtype: —

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

SPERMATOGENESIS+0.195
E2F_TARGETS+0.190
G2M_CHECKPOINT+0.138
PROTEIN_SECRETION+0.074
GLYCOLYSIS+0.005
ANGIOGENESIS+0.001
UNFOLDED_PROTEIN_RESPONSE-0.015
MTORC1_SIGNALING-0.029
BILE_ACID_METABOLISM-0.030
DNA_REPAIR-0.052

Top 10 suppressed

APICAL_SURFACE-0.454
APICAL_JUNCTION-0.437
WNT_BETA_CATENIN_SIGNALING-0.425
EPITHELIAL_MESENCHYMAL_TRANSITION-0.423
HEDGEHOG_SIGNALING-0.402
INTERFERON_ALPHA_RESPONSE-0.379
TGF_BETA_SIGNALING-0.360
PEROXISOME-0.330
MYOGENESIS-0.329
ESTROGEN_RESPONSE_EARLY-0.328

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

5 twins match this tumor's tissue · 5 come from a different tissue of origin ← cross-tissue dominant

#	Sample	Cancer type	Subtype	cos similarity
1	TCGA-PK-A5H8-01 acc-tcga-pancan-2018@2018	Adrenocortical Carcinoma	Adrenocortical Carcinoma, Usual Type	0.873
2	SRR10842347 melanoma-umap@29	—	—	0.870
3	BS_KN92S7YQ brain-umap@2	medulloblastoma	—	0.859
4	SRR8752376 head-neck@1	—	—	0.857
5	TCGA-BB-4224-01A-01R-1436-07 head-neck@1	—	—	0.853
6	BS_5PJCHF6V brain-umap@2	medulloblastoma	—	0.836
7	BS_61E80SD6 brain-umap@2	medulloblastoma	—	0.836
8	TCGA-4Z-AA7M-01A-11R-A39I-07 bladder-landscape@3	—	—	0.834
9	BS_W311713R brain-umap@2	medulloblastoma	—	0.830
10	SRR10899998 melanoma-umap@29	—	—	0.830

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 6 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)	tumor score	Best drug	reversal magnitude
SPERMATOGENESIS	0.195	Inavolisib	— uncovered
E2F_TARGETS	0.190	Inavolisib	— uncovered
G2M_CHECKPOINT	0.138	Inavolisib	— uncovered
PROTEIN_SECRETION	0.074	Remibrutinib	— uncovered
GLYCOLYSIS	0.005	Inavolisib	— uncovered
ANGIOGENESIS	0.001	Remibrutinib	— uncovered