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TCGA-E2-A14U-01A-11R-A22K-07

· A

ea7679ff-cdac-5182-aeda-67a8926b4f72

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
A
subtype
A
overall_survival_months
44

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-D8-A3Z5-01A-41R-A24H-07
breast-umap@18
A0.927
2SRR1313116
breast-umap@18
A0.908
3TCGA-OL-A5RV-01A-12R-A28M-07
breast-umap@18
A0.903
4AUR-AEPZ-TTP1-A-1-1-R-A742-41
breast-umap@18
B0.887
5TCGA-W8-A86G-01A-21R-A36F-07
breast-umap@18
A0.884
6TCGA-B6-A0RQ-01A-11R-A115-07
breast-umap@18
A0.872
7R76
bladder-landscape@3
0.859
8TCGA-GM-A3XG-01A-31R-A24H-07
breast-umap@18
A0.852
9s0112264
melanoma-umap@29
0.842
10s0112300
melanoma-umap@29
0.838

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 13 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
WNT_BETA_CATENIN_SIGNALING0.420Inavolisib— uncovered
ESTROGEN_RESPONSE_EARLY0.380Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.280Idelalisib— uncovered
P53_PATHWAY0.270Idelalisib— uncovered
KRAS_SIGNALING_DN0.220Remibrutinib— uncovered
BILE_ACID_METABOLISM0.160Inavolisib— uncovered
MYOGENESIS0.150Inavolisib— uncovered
XENOBIOTIC_METABOLISM0.140Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.100Inavolisib— uncovered
APICAL_JUNCTION0.060Inavolisib— uncovered
HYPOXIA0.030Idelalisib— uncovered
FATTY_ACID_METABOLISM0.020Inavolisib— uncovered
NOTCH_SIGNALING0.010Inavolisib— uncovered