SRR9879275

— · cohortA1

ec0f52e4-3216-5fa4-b9b5-1f5f8d478b9a

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type: —
cancer_type_detailed: —
subtype: cohortA1
subtype: cohortA1

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

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Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#	Sample	Cancer type	Subtype	cos similarity
1	TCGA-66-2771-01A-01R-0980-07 lung-landscapes@6	—	cohortSQ1	0.865
2	2ad90ba0-8038-4bad-afa3-d176f63b42f0 colon-landscapes@1	—	—	0.860
3	TCGA-37-3783-01A-01R-1201-07 lung-landscapes@6	—	cohortSQ1	0.852
4	e0464181-da72-4a14-9039-a396843c39f2 colon-landscapes@1	—	—	0.851
5	a8e85cdd-3770-40a0-837e-6962ec12fcf0 colon-landscapes@1	—	—	0.847
6	a3b44031-71ef-476f-a8bd-3694226ce026 colon-landscapes@1	—	—	0.843
7	SRR27320676 colon-landscapes@1	—	—	0.836
8	SRR23036888 head-neck@1	—	—	0.833
9	992ce1bc-46a2-4f57-ac7a-c6368c69c67c colon-landscapes@1	—	—	0.832
10	bc895549-854b-484f-8a6d-9e5152829bcb colon-landscapes@1	—	—	0.830

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 30 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)	tumor score	Best drug	reversal magnitude
OXIDATIVE_PHOSPHORYLATION	0.530	Remibrutinib	— uncovered
ALLOGRAFT_REJECTION	0.450	Idelalisib	— uncovered
MYC_TARGETS_V1	0.410	Inavolisib	— uncovered
MTORC1_SIGNALING	0.360	Inavolisib	— uncovered
HYPOXIA	0.350	Idelalisib	— uncovered
INTERFERON_ALPHA_RESPONSE	0.340	Inavolisib	— uncovered
GLYCOLYSIS	0.330	Inavolisib	— uncovered
FATTY_ACID_METABOLISM	0.320	Inavolisib	— uncovered
INFLAMMATORY_RESPONSE	0.320	Idelalisib	— uncovered
E2F_TARGETS	0.300	Inavolisib	— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY	0.300	Inavolisib	— uncovered
COMPLEMENT	0.290	Inavolisib	— uncovered
INTERFERON_GAMMA_RESPONSE	0.280	Idelalisib	— uncovered
DNA_REPAIR	0.230	Idelalisib	— uncovered
UV_RESPONSE_UP	0.220	Idelalisib	— uncovered
IL6_JAK_STAT3_SIGNALING	0.200	Inavolisib	— uncovered
ADIPOGENESIS	0.190	Inavolisib	— uncovered
PANCREAS_BETA_CELLS	0.190	Cobimetinib	— uncovered
TNFA_SIGNALING_VIA_NFKB	0.190	Inavolisib	— uncovered
HEME_METABOLISM	0.170	Temsirolimus	— uncovered