Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

ERR2598335

fetal · fetal

ee0482d4-0272-5d7f-b67c-4cadff20213b

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
fetal
cancer_type_detailed
subtype
fetal
cancer_type
fetal
subtype
fetal
sex
fetal
race
fetal
fetal_age_forebrain
22
umap1_2d
-2.311183911
umap2_2d
5.048616841
umap1_3d
1.10406646
umap2_3d
0.852120559
umap3_3d
0.215422728
dataset
fetal

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • OXIDATIVE_PHOSPHORYLATION+0.400
  • COAGULATION+0.370
  • INTERFERON_ALPHA_RESPONSE+0.370
  • INFLAMMATORY_RESPONSE+0.350
  • SPERMATOGENESIS+0.330
  • ALLOGRAFT_REJECTION+0.320
  • MYOGENESIS+0.320
  • COMPLEMENT+0.290
  • KRAS_SIGNALING_DN+0.290
  • PANCREAS_BETA_CELLS+0.290

Top 10 suppressed

  • G2M_CHECKPOINT-0.580
  • E2F_TARGETS-0.570
  • MITOTIC_SPINDLE-0.470
  • MYC_TARGETS_V1-0.390
  • MYC_TARGETS_V2-0.390
  • WNT_BETA_CATENIN_SIGNALING-0.380
  • HEDGEHOG_SIGNALING-0.370
  • NOTCH_SIGNALING-0.340
  • UNFOLDED_PROTEIN_RESPONSE-0.320
  • PROTEIN_SECRETION-0.310

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

8 twins match this tumor's tissue · 2 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1ERR2598280
medullo-epn-umap@date-based
fetalfetal0.957
2ERR2598329
medullo-epn-umap@date-based
fetalfetal0.954
3ERR2598269
medullo-epn-umap@date-based
fetalfetal0.948
4ERR2598328
medullo-epn-umap@date-based
fetalfetal0.945
5ERR2598268
medullo-epn-umap@date-based
fetalfetal0.941
6ERR2598281
medullo-epn-umap@date-based
fetalfetal0.919
7ERR2598267
medullo-epn-umap@date-based
fetalfetal0.914
8TCGA-50-6597-01A-11R-1858-07
lung-landscapes@6
cohortA10.885
9MDT-AP-2579
medullo-epn-umap@date-based
MedMedulloblastoma0.884
10SRR1436106
brain-umap@2
GTEX0.876

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 28 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
OXIDATIVE_PHOSPHORYLATION0.400Remibrutinib— uncovered
COAGULATION0.370Binimetinib— uncovered
INTERFERON_ALPHA_RESPONSE0.370Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.350Idelalisib— uncovered
SPERMATOGENESIS0.330Inavolisib— uncovered
ALLOGRAFT_REJECTION0.320Idelalisib— uncovered
MYOGENESIS0.320Inavolisib— uncovered
COMPLEMENT0.290Inavolisib— uncovered
KRAS_SIGNALING_DN0.290Remibrutinib— uncovered
PANCREAS_BETA_CELLS0.290Cobimetinib— uncovered
FATTY_ACID_METABOLISM0.270Inavolisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.270Inavolisib— uncovered
XENOBIOTIC_METABOLISM0.270Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.250Idelalisib— uncovered
KRAS_SIGNALING_UP0.230Inavolisib— uncovered
APICAL_SURFACE0.210Temsirolimus— uncovered
BILE_ACID_METABOLISM0.190Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.190Idelalisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.190Inavolisib— uncovered
UV_RESPONSE_UP0.160Idelalisib— uncovered