Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · brain-umap@2

SRR1331289

GTEX

ef3facd8-ff85-59d9-82d2-f38bbc079fd1

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
GTEX
cancer_type_detailed
—
subtype
—
cancer_type
GTEX
sex
Male

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • INFLAMMATORY_RESPONSE+0.466
  • KRAS_SIGNALING_DN+0.430
  • IL6_JAK_STAT3_SIGNALING+0.416
  • COAGULATION+0.392
  • ALLOGRAFT_REJECTION+0.380
  • EPITHELIAL_MESENCHYMAL_TRANSITION+0.365
  • KRAS_SIGNALING_UP+0.294
  • PANCREAS_BETA_CELLS+0.286
  • INTERFERON_GAMMA_RESPONSE+0.280
  • COMPLEMENT+0.276

Top 10 suppressed

  • OXIDATIVE_PHOSPHORYLATION-0.670
  • MYC_TARGETS_V1-0.647
  • MYC_TARGETS_V2-0.580
  • DNA_REPAIR-0.550
  • UNFOLDED_PROTEIN_RESPONSE-0.540
  • PROTEIN_SECRETION-0.496
  • MTORC1_SIGNALING-0.485
  • REACTIVE_OXYGEN_SPECIES_PATHWAY-0.410
  • CHOLESTEROL_HOMEOSTASIS-0.399
  • PI3K_AKT_MTOR_SIGNALING-0.387

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR1375616
brain-umap@2
GTEX—0.984
2SRR1429957
brain-umap@2
GTEX—0.979
3SRR820292
brain-umap@2
GTEX—0.977
4SRR598894
brain-umap@2
GTEX—0.976
5SRR1374115
brain-umap@2
GTEX—0.976
6SRR1456333
brain-umap@2
GTEX—0.973
7SRR1417070
brain-umap@2
GTEX—0.973
8SRR819793
brain-umap@2
GTEX—0.970
9SRR1362464
brain-umap@2
GTEX—0.967
10SRR1476614
brain-umap@2
GTEX—0.966

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 23 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
INFLAMMATORY_RESPONSE0.466Idelalisib— uncovered
KRAS_SIGNALING_DN0.430Remibrutinib— uncovered
IL6_JAK_STAT3_SIGNALING0.416Inavolisib— uncovered
COAGULATION0.392Binimetinib— uncovered
ALLOGRAFT_REJECTION0.380Idelalisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.365Inavolisib— uncovered
KRAS_SIGNALING_UP0.294Inavolisib— uncovered
PANCREAS_BETA_CELLS0.286Cobimetinib— uncovered
INTERFERON_GAMMA_RESPONSE0.280Idelalisib— uncovered
COMPLEMENT0.276Inavolisib— uncovered
INTERFERON_ALPHA_RESPONSE0.256Inavolisib— uncovered
ANGIOGENESIS0.228Remibrutinib— uncovered
APICAL_SURFACE0.227Temsirolimus— uncovered
MYOGENESIS0.220Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.196Idelalisib— uncovered
IL2_STAT5_SIGNALING0.195Idelalisib— uncovered
SPERMATOGENESIS0.175Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.169Inavolisib— uncovered
BILE_ACID_METABOLISM0.165Inavolisib— uncovered
ESTROGEN_RESPONSE_EARLY0.160Inavolisib— uncovered