SRR934738
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- TGF_BETA_SIGNALING+0.424
- PROTEIN_SECRETION+0.417
- MITOTIC_SPINDLE+0.404
- HEDGEHOG_SIGNALING+0.357
- INTERFERON_ALPHA_RESPONSE+0.349
- CHOLESTEROL_HOMEOSTASIS+0.325
- NOTCH_SIGNALING+0.255
- MTORC1_SIGNALING+0.249
- ADIPOGENESIS+0.237
- ANDROGEN_RESPONSE+0.237
Top 10 suppressed
- KRAS_SIGNALING_DN-0.356
- APICAL_SURFACE-0.291
- TNFA_SIGNALING_VIA_NFKB-0.246
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.230
- MYC_TARGETS_V2-0.215
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.202
- SPERMATOGENESIS-0.179
- ANGIOGENESIS-0.170
- MYOGENESIS-0.163
- ESTROGEN_RESPONSE_LATE-0.129
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR934788 | — | — | 0.824 |
| 2 | SRR934754 | — | — | 0.811 |
| 3 | AFCB278F-0EFB-4999-8D2C-C72B89A8403E | — | — | 0.810 |
| 4 | SRR934725 | — | — | 0.807 |
| 5 | SRR934795 | — | — | 0.801 |
| 6 | SRR934762 | — | — | 0.798 |
| 7 | 21D48ADE-2798-4380-999A-9485A70E7D2A | — | — | 0.784 |
| 8 | SRR934783 | — | — | 0.783 |
| 9 | 10EE3CFC-9230-40BA-9C9F-77949BA763CC | — | — | 0.772 |
| 10 | SRR934819 | — | — | 0.766 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 29 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| TGF_BETA_SIGNALING | 0.424 | Inavolisib | — uncovered |
| PROTEIN_SECRETION | 0.417 | Remibrutinib | — uncovered |
| MITOTIC_SPINDLE | 0.404 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.357 | Inavolisib | — uncovered |
| INTERFERON_ALPHA_RESPONSE | 0.349 | Inavolisib | — uncovered |
| CHOLESTEROL_HOMEOSTASIS | 0.325 | Remibrutinib | — uncovered |
| NOTCH_SIGNALING | 0.255 | Inavolisib | — uncovered |
| MTORC1_SIGNALING | 0.249 | Inavolisib | — uncovered |
| ADIPOGENESIS | 0.237 | Inavolisib | — uncovered |
| ANDROGEN_RESPONSE | 0.237 | Inavolisib | — uncovered |
| HEME_METABOLISM | 0.219 | Temsirolimus | — uncovered |
| UV_RESPONSE_DN | 0.216 | Inavolisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.204 | Inavolisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.184 | Idelalisib | — uncovered |
| BILE_ACID_METABOLISM | 0.177 | Inavolisib | — uncovered |
| G2M_CHECKPOINT | 0.172 | Inavolisib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.140 | Inavolisib | — uncovered |
| IL6_JAK_STAT3_SIGNALING | 0.121 | Inavolisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.118 | Idelalisib | — uncovered |
| IL2_STAT5_SIGNALING | 0.104 | Idelalisib | — uncovered |