Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

SRR934833

f01466ce-b692-5142-98a9-b5fbcd152f1a

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
72.89750328515112
age_years
53
sex
Female

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • INTERFERON_ALPHA_RESPONSE+0.625
  • INTERFERON_GAMMA_RESPONSE+0.531
  • ALLOGRAFT_REJECTION+0.438
  • PROTEIN_SECRETION+0.438
  • TGF_BETA_SIGNALING+0.422
  • IL6_JAK_STAT3_SIGNALING+0.399
  • IL2_STAT5_SIGNALING+0.369
  • MITOTIC_SPINDLE+0.367
  • INFLAMMATORY_RESPONSE+0.362
  • ANDROGEN_RESPONSE+0.318

Top 10 suppressed

  • PANCREAS_BETA_CELLS-0.424
  • KRAS_SIGNALING_DN-0.377
  • SPERMATOGENESIS-0.279
  • ESTROGEN_RESPONSE_LATE-0.148
  • MYOGENESIS-0.144
  • ANGIOGENESIS-0.117
  • E2F_TARGETS-0.077
  • ESTROGEN_RESPONSE_EARLY-0.050
  • HYPOXIA-0.005
  • G2M_CHECKPOINT+0.002

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
16292335B-7CBB-45BE-AA2A-B39FFDA8768D
brain-umap@2
0.921
2896B5096-D888-4DC3-9C70-152BDE083E26
brain-umap@2
0.918
3B4E10042-052D-4DC4-BC94-FF1D5D4632C0
brain-umap@2
0.909
49ECB653A-A04F-457C-92FC-D13424511A47
brain-umap@2
0.906
5C1CCE12B-8892-49AB-8DF2-E5E280DEAE32
brain-umap@2
0.903
61C62E679-3A4E-4D10-8BFB-5BFBF2A3B4B6
brain-umap@2
0.900
7SRR934807
brain-umap@2
0.898
8385ECC71-2BF4-4E14-B2CC-8423E79BDEBE
brain-umap@2
0.897
9SRR934830
brain-umap@2
0.893
10SRR934811
brain-umap@2
0.893

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 41 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
INTERFERON_ALPHA_RESPONSE0.625Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.531Idelalisib— uncovered
ALLOGRAFT_REJECTION0.438Idelalisib— uncovered
PROTEIN_SECRETION0.438Remibrutinib— uncovered
TGF_BETA_SIGNALING0.422Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.399Inavolisib— uncovered
IL2_STAT5_SIGNALING0.369Idelalisib— uncovered
MITOTIC_SPINDLE0.367Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.362Idelalisib— uncovered
ANDROGEN_RESPONSE0.318Inavolisib— uncovered
NOTCH_SIGNALING0.317Inavolisib— uncovered
ADIPOGENESIS0.308Inavolisib— uncovered
COMPLEMENT0.308Inavolisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.242Remibrutinib— uncovered
APOPTOSIS0.239Idelalisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.215Inavolisib— uncovered
MTORC1_SIGNALING0.214Inavolisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.194Idelalisib— uncovered
HEME_METABOLISM0.190Temsirolimus— uncovered
UV_RESPONSE_DN0.186Inavolisib— uncovered