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SRR8518452

· A

f25bd97c-d028-560a-861c-1c4f7a320466

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
A
subtype
A

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

8 twins match this tumor's tissue · 2 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR5088840
melanoma-umap@29
0.861
2BS_ET8CJXSF
brain-umap@2
pilocytic astrocytoma0.852
3BS_CGB2WS2A
brain-umap@2
pilocytic astrocytoma0.830
4s0112300
melanoma-umap@29
0.827
5C3N-00223
lung-landscapes@6
cohortA10.827
6SRR5088841
melanoma-umap@29
0.826
7SRR1313109
breast-umap@18
A0.814
8s0112302
melanoma-umap@29
0.807
9SRR8518381
breast-umap@18
A0.807
10SRR12696784
melanoma-umap@29
0.803

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 18 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
ADIPOGENESIS0.460Inavolisib— uncovered
FATTY_ACID_METABOLISM0.390Inavolisib— uncovered
BILE_ACID_METABOLISM0.360Inavolisib— uncovered
XENOBIOTIC_METABOLISM0.280Inavolisib— uncovered
MYOGENESIS0.260Inavolisib— uncovered
UV_RESPONSE_DN0.250Inavolisib— uncovered
ESTROGEN_RESPONSE_EARLY0.200Inavolisib— uncovered
PEROXISOME0.190Idelalisib— uncovered
ANDROGEN_RESPONSE0.130Inavolisib— uncovered
KRAS_SIGNALING_DN0.120Remibrutinib— uncovered
KRAS_SIGNALING_UP0.100Inavolisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.090Remibrutinib— uncovered
OXIDATIVE_PHOSPHORYLATION0.060Remibrutinib— uncovered
P53_PATHWAY0.060Idelalisib— uncovered
PANCREAS_BETA_CELLS0.060Cobimetinib— uncovered
ESTROGEN_RESPONSE_LATE0.030Idelalisib— uncovered
HEME_METABOLISM0.030Temsirolimus— uncovered
APICAL_JUNCTION0.010Inavolisib— uncovered