Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-CF-A8HY-01A-11R-A36F-07

f60595f6-832e-5e68-bbac-d3c2b6839856

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
11.33377135
os_event
false
sex
Male

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • OXIDATIVE_PHOSPHORYLATION+0.390
  • PANCREAS_BETA_CELLS+0.370
  • COAGULATION+0.280
  • HYPOXIA+0.270
  • MYC_TARGETS_V2+0.270
  • REACTIVE_OXYGEN_SPECIES_PATHWAY+0.240
  • P53_PATHWAY+0.200
  • KRAS_SIGNALING_DN+0.190
  • CHOLESTEROL_HOMEOSTASIS+0.170
  • GLYCOLYSIS+0.170

Top 10 suppressed

  • INTERFERON_ALPHA_RESPONSE-0.450
  • INTERFERON_GAMMA_RESPONSE-0.450
  • PROTEIN_SECRETION-0.420
  • UV_RESPONSE_DN-0.420
  • MITOTIC_SPINDLE-0.410
  • G2M_CHECKPOINT-0.370
  • E2F_TARGETS-0.320
  • INFLAMMATORY_RESPONSE-0.320
  • ALLOGRAFT_REJECTION-0.260
  • EPITHELIAL_MESENCHYMAL_TRANSITION-0.250

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1MNG1265
mng-umap@100
0.852
2TCGA-UF-A7JF-01A-11R-A34R-07
head-neck@1
0.815
3TCGA-CF-A5UA-01A-11R-A28M-07
bladder-landscape@3
0.809
4TCGA-GU-A767-01A-11R-A32O-07
bladder-landscape@3
0.797
50ffd0bed-35a4-4fec-9d56-1d4ae5dcb507
colon-landscapes@1
0.795
6TCGA-LL-A5YM-01A-11R-A28M-07
breast-umap@18
B0.788
7R20
bladder-landscape@3
0.779
8TCGA-V7-A7HQ-01A-11R-A33J-07
breast-umap@18
B0.777
985d43afd-9aac-48ca-a9c4-00357b7207e1
melanoma-umap@29
0.774
10SRR9879286
lung-landscapes@6
cohortSQ20.766

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 23 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
OXIDATIVE_PHOSPHORYLATION0.390Remibrutinib— uncovered
PANCREAS_BETA_CELLS0.370Cobimetinib— uncovered
COAGULATION0.280Binimetinib— uncovered
HYPOXIA0.270Idelalisib— uncovered
MYC_TARGETS_V20.270Idelalisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.240Inavolisib— uncovered
P53_PATHWAY0.200Idelalisib— uncovered
KRAS_SIGNALING_DN0.190Remibrutinib— uncovered
CHOLESTEROL_HOMEOSTASIS0.170Remibrutinib— uncovered
GLYCOLYSIS0.170Inavolisib— uncovered
MYC_TARGETS_V10.150Inavolisib— uncovered
MYOGENESIS0.140Inavolisib— uncovered
UV_RESPONSE_UP0.130Idelalisib— uncovered
ADIPOGENESIS0.100Inavolisib— uncovered
DNA_REPAIR0.100Idelalisib— uncovered
ESTROGEN_RESPONSE_LATE0.080Idelalisib— uncovered
FATTY_ACID_METABOLISM0.080Inavolisib— uncovered
APICAL_SURFACE0.060Temsirolimus— uncovered
ESTROGEN_RESPONSE_EARLY0.060Inavolisib— uncovered
NOTCH_SIGNALING0.060Inavolisib— uncovered