Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

be297c26-df4c-4ae2-a117-a8c6d1cfb421

f6df92c4-389c-5f5b-9b75-38a26d270b0c

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
age_years
79

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
13E499D12-B08A-491C-98C6-19EA420BDC99
brain-umap@2
0.945
297A8E2B1-059B-4527-8FB4-116F718FFD16
brain-umap@2
0.945
3AB5294B5-4A59-493A-9016-C2778735745F
brain-umap@2
0.938
4FBB4DAFD-11F1-498F-95C5-73D8B735465B
brain-umap@2
0.937
5BDBF3ACE-7DC0-47C1-9B03-E2EDCF0B6CE6
brain-umap@2
0.931
6E89DB941-19C3-4CD9-9117-EAAF3B2AFD76
brain-umap@2
0.929
7B8AED170-C88C-4A86-8377-93B5D14AB334
brain-umap@2
0.923
853B31ABD-AD68-4A44-A525-23FD413115D5
brain-umap@2
0.923
99E5B5D00-45A2-48A9-9F57-0B4AAE9E4E25
brain-umap@2
0.923
1027875588-7C41-49BB-A4C0-A66D72A12499
brain-umap@2
0.920

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 39 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
MTORC1_SIGNALING0.540Inavolisib— uncovered
MYC_TARGETS_V10.520Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.480Idelalisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.470Remibrutinib— uncovered
ANGIOGENESIS0.460Remibrutinib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.460Inavolisib— uncovered
ALLOGRAFT_REJECTION0.450Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.450Inavolisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.440Inavolisib— uncovered
E2F_TARGETS0.390Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.390Idelalisib— uncovered
PROTEIN_SECRETION0.390Remibrutinib— uncovered
COMPLEMENT0.380Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.370Inavolisib— uncovered
ANDROGEN_RESPONSE0.360Inavolisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.350Inavolisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.350Idelalisib— uncovered
GLYCOLYSIS0.330Inavolisib— uncovered
KRAS_SIGNALING_UP0.310Inavolisib— uncovered
G2M_CHECKPOINT0.300Inavolisib— uncovered